阻塞性睡眠呼吸暂停综合征患者心血管事件的风险评估和预防:一项叙述性综述

IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE
Bin Li, HuiQian Yang, XiaoXu Lv, Xu Guo, FengLei Xu, XiaoMing Li
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引用次数: 0

摘要

研究目的阻塞性睡眠呼吸暂停综合征(OSAS)是多种慢性疾病的病因,其靶器官损害以心血管并发症最为常见和严重。OSAS长期干预的主要目的不仅是纠正睡眠结构,减少低氧血症的发生,而且要减轻心血管系统的负担,降低心血管疾病的发生风险,提高患者的生活质量。方法于2019年1月1日至2024年5月30日在PubMed、SCOPUS和谷歌Scholar中进行文献检索。还对过去五年中与OSAS对心血管事件的影响有关的研究进行了全面的叙述性审查。这包括对OSAS和各种心血管疾病的发病率、生理机制、风险指标和干预措施的概述。结果近年来的文献和研究表明,OSAS患病率与心血管疾病风险存在显著相关性,轮班工作障碍等一些独特的动态因素在评估OSAS患者心血管事件风险中起重要作用;然而,新的诊断工具和治疗策略需要进一步研究和开发,以更好地满足临床管理的需要。结论全面评估OSAS相关的心血管风险,采用必要的筛查工具和有针对性的干预措施,包括药物、手术、CPAP或生活方式的改变,可有效减少甚至预防其对靶器官的损害。OSAS长期干预的主要目的不仅是纠正睡眠结构,减少低氧血症的发生,而且要减轻心血管系统的负担,降低心血管疾病的发生风险,提高患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk assessment and prevention of cardiovascular events in patients with obstructive sleep apnea syndrome: A narrative review

Study objectives

Obstructive sleep apnea syndrome (OSAS) is a causative agent of a wide range of chronic diseases, and its target organ damage is characterized by cardiovascular complications that are most common and severe. The primary objective of long-term intervention for OSAS is not only to correct the sleep architecture and reduce the incidence of hypoxemia, but also to alleviate the cardiovascular system's burden, decrease the risk of cardiovascular disease, and enhance patients' quality of life.

Methods

A literature search of PubMed, SCOPUS, and Google Scholar was conducted from January 1, 2019, to May 30, 2024. A comprehensive narrative review of studies related to the impact of OSAS on cardiovascular events in the last five years was also conducted. This includes an overview of the incidence, physiologic mechanisms, risk indicators, and interventions for OSAS and various cardiovascular diseases.

Results

Recent literature and studies have shown that there is a significant correlation between the prevalence of OSAS and the risk of cardiovascular disease, and that some unique dynamic factors such as shift work disorders play an important role in the assessment of the risk of cardiovascular events in patients with OSAS; however, new diagnostic tools and therapeutic strategies need to be further researched and developed to better meet the needs of clinical management.

Conclusions

A comprehensive assessment of the cardiovascular risk associated with OSAS, utilizing the necessary screening tools and targeted interventions, including the application of drugs, surgery, CPAP, or lifestyle modifications, can effectively reduce or even prevent damage to its target organs. The main goal of long-term intervention for OSAS is not only to correct the sleep architecture and reduce the occurrence of hypoxemia, but also to reduce the burden on the cardiovascular system, reduce the risk of cardiovascular disease, and improve the quality of life of patients.
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