环境空气污染暴露和睡眠模式与大脑结构的关联：英国生物银行的一项前瞻性研究

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-06-23 DOI:10.1016/j.ecoenv.2025.118517

Ting Song , Xiyin Qiu , Jialong Wu, Huan Xu, Juying Zhang, Bing Guo, Xing Zhao

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引用次数: 0

摘要

先前的研究表明，暴露于空气污染（AP）与总灰质体积（GMV）和总白质体积（WMV）之间存在关联。然而，没有研究探索睡眠条件（睡眠行为和睡眠模式）对AP和大脑结构之间关系的影响。方法本研究包括来自英国生物银行的21,000多名参与者。对神经成像数据进行处理，以获得全脑体积、GMV和WMV以及白质高强度体积（WMHV）的测量。利用土地利用回归模型估算PM2.5、PM2.5 - 10、PM10、NO2、NOx和PM2.5吸光度等AP浓度。睡眠行为包括时间类型、持续时间、失眠、打鼾和白天嗜睡。这些行为被用来计算健康睡眠得分，然后将睡眠模式分为健康、中等和较差。双稳健方法用于估计AP、睡眠条件和大脑结构之间的关联。结果PM2.5、NO2、NOX和PM2.5吸光度与脑区、GMV和WMV呈显著负相关。PM2.5、NO2和NOX与WMHV呈显著正相关，β（95 %CI）系数分别为0.016（0.005,0.027）、0.016（0.005,0.026）和0.018（0.006,0.031）。睡眠模式与全球大脑和WMV呈正相关。睡眠时间改变了三种AP （PM2.5、PM10、PM2.5吸光度）与WMHV之间的相关性（P互作<；0.05）。随着睡眠模式的改善，PM2.5和NO2与全球大脑和WMV的关联减弱。结论睡眠不足与大脑预后的不良影响有关，而健康的睡眠条件与良好的大脑预后有关。低风险的睡眠行为和健康的睡眠模式可以减轻AP与大脑结构的有害关联。

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Associations of ambient air pollution exposure and sleep pattern with brain structures: A prospective study in the UK Biobank

Background

Previous studies have shown associations between exposure to air pollution (AP) and total gray matter volume (GMV) and total white matter volume (WMV). However, no study has explored the impact of sleep conditions (sleep behaviors and sleep patterns) on the associations between AP and brain structures.

Methods

This study included over 21,000 participants from the UK Biobank. Neuroimaging data were processed to obtain measures of global brain volume, GMV, and WMV, as well as white matter hyperintensity volume (WMHV). Land use regression model was utilized to estimate the concentrations of AP, including PM_2.5, PM_2.5–10, PM₁₀, NO₂, NO_x, and PM_{2.5absorbance}. Sleep behaviors included chronotype, duration, insomnia, snoring, and daytime sleepiness. These behaviors were utilized to calculate a healthy sleep score and then applied to categorize sleep patterns as healthy, intermediate, or poor. The doubly robust method was used to estimate the associations between AP, sleep conditions, and brain structures.

Results

This study found that PM_2.5, NO₂, NO_X, and PM_{2.5absorbance} were significantly inversely associated with global brain, GMV and WMV. PM_2.5, NO₂, and NO_X showed significant positive associations with WMHV, with β (95 %CI) coefficients of 0.016 (0.005, 0.027), 0.016 (0.005, 0.026), and 0.018 (0.006, 0.031), respectively. Sleep patterns were positively associated with global brain and WMV. Sleep duration modified the associations between the three kinds of AP (PM_2.5, PM₁₀, PM_{2.5absorbance}) and WMHV (P _interaction<0.05). The associations of PM_2.5 and NO₂ with the global brain and WMV decreased as sleep patterns improved.

Conclusions

AP was associated with adverse effects on brain outcomes, while healthy sleep conditions were linked to favorable brain outcomes. Low-risk sleep behaviors and healthy sleep pattern may mitigate the detrimental associations of AP with brain structures.

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.