检查父母教育和童年逆境与妊娠糖尿病风险的联合关系：丹麦的一项全国性登记研究。

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetic Medicine Pub Date : 2025-06-20 DOI:10.1111/dme.70091

Hiroaki Onizuka, Naja H. Rod, Karoline Kragelund Nielsen, Peter Damm, Megan Davies

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引用次数: 0

摘要

目的：儿童时期父母教育水平低可能增加儿童对逆境的脆弱性，这是已知的增加妊娠期糖尿病（GDM）的风险。我们的目的是检查父母教育和童年逆境与GDM风险的联合关系。方法：我们使用了2004-2018年期间丹麦全国206819名首次分娩妇女的登记数据。五个逆境组被用来衡量童年的逆境：低逆境、早期物质剥夺、持续剥夺、损失或损失威胁、高逆境。本研究采用低、中、高等教育三个层次的父母教育水平，以高等教育和低逆境为参照组，通过乘法和加性尺度的交互作用，考察了父母教育水平和童年逆境对GDM风险的共同影响。结果：4758名（2.3%）女性在研究人群中被诊断为GDM。我们发现父母教育和童年逆境与GDM风险有显著的联合关系。与父母受教育程度高、童年逆境低的女性相比，父母受教育程度低、经历过损失或损失威胁的女性患GDM的风险更高(or 2.60 [95% CI 2.15；3.12])。累加性量表虽未达到统计学意义，但具有一定的累加性；累加性量表无交互作用。结论：父母教育程度低和童年逆境均可进一步增加GDM的风险。旨在为低社会经济地位家庭提供更好的支持和资源的结构性干预可能会降低GDM的风险。

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Examining the joint association of parental education and childhood adversities on gestational diabetes risk: A nationwide register study from Denmark

Aims

Low parental education during childhood may increase vulnerability to childhood adversities, which is known to increase the risk of gestational diabetes mellitus (GDM). We aimed to examine the joint association of parental education and childhood adversity on GDM risk.

Methods

We used Danish nationwide register data of 206,819 women giving birth for the first time during 2004–2018. Five adversity groups were used to measure childhood adversity: low adversity, early material deprivation, persistent deprivation, loss or threat of loss, and high adversity. We examined the joint association of parental education and childhood adversity on GDM risk through interaction at the multiplicative and additive scale, using three levels of parental education: low, medium and high education, with high education and low adversity as the referent group.

Results

4758 (2.3%) women were diagnosed with GDM in the study population. We found a significant joint association of parental education and childhood adversity on GDM risk. Women with a low parental education level and who experienced loss or threat of loss had a higher risk of GDM compared to women with a high parental education level and low childhood adversity (OR 2.60 [95% CI 2.15; 3.12]). The additive scale showed some additivity though did not reach statistical significance, and there was no evidence of interaction on the multiplicative scale.

Conclusions

Having both exposure to low parental education and childhood adversity may further increase the risk of GDM. Structural interventions aimed at providing better support and resources for low socioeconomic status families may reduce the risk of GDM.

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来源期刊

Diabetic Medicine 医学-内分泌学与代谢

CiteScore

7.20

自引率

5.70%

发文量

229

审稿时长

3-6 weeks

期刊介绍： Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”