Renee van der Schaaf, Vanessa E. Murphy, Soriah Harvey, Paige Dent, Alison Lane, Olivia Whalen
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Compared to women without asthma, there was an increased odds of child autism with any history of maternal asthma (OR = 1.32; 95% CI = 1.21, 1.44; <i>I</i><sup>2</sup> = 61%, <i>n</i> = 14), with current asthma during pregnancy (OR = 1.23; 95% CI = 1.12, 1.35; <i>I</i><sup>2</sup> = 35%, <i>n</i> = 10) and with medication use during pregnancy (OR = 1.48; 95% CI = 1.30, 1.68; <i>I</i><sup>2</sup> = 0%, <i>n</i> = 3). However, when women with asthma who used asthma medication were compared to those with asthma who did not use medication, there were no increased odds for child autism (OR = 1.07; 95% CI = 0.89, 1.27; <i>I</i><sup>2</sup> = 34%, <i>n</i> = 2). Maternal asthma is associated with an increased odds of child autism. 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引用次数: 0
摘要
母亲的哮喘与儿童自闭症有关。在这项研究中,我们系统地回顾了2001年7月至2024年2月期间发表的观察性研究,这些研究评估了怀孕期间母亲哮喘(暴露)和儿童自闭症(结果)。检索的数据库包括MEDLINE、CINAHL、EMBASE和PsycINFO。在350项潜在研究中,19项符合纳入标准(2,530,716名受试者;73065名自闭症参与者)。用纽卡斯尔-渥太华量表评估质量。采用随机效应模型的Mantel-Haenszel方法,采用比例和优势比进行meta分析。与没有哮喘的妇女相比,母亲有哮喘史的儿童患自闭症的几率增加(OR = 1.32;95% ci = 1.21, 1.44;I2 = 61%, n = 14),妊娠期有哮喘(OR = 1.23;95% ci = 1.12, 1.35;I2 = 35%, n = 10),与妊娠期间用药有关(OR = 1.48;95% ci = 1.30, 1.68;I2 = 0%, n = 3)。然而,当使用哮喘药物的哮喘妇女与不使用哮喘药物的哮喘妇女进行比较时,儿童自闭症的几率没有增加(OR = 1.07;95% ci = 0.89, 1.27;I2 = 34%, n = 2)。母亲患哮喘与儿童患自闭症的几率增加有关。未来的研究应该考虑父母的神经分化,哮喘的严重程度,以及治疗母亲哮喘的处方药物的有效性,以提高我们对这种关联的理解。试验注册:PROSPERO注册号:CRD42021265060。
The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis
Maternal asthma has been linked to child autism. In this study, we systematically reviewed observational studies published between July 2001 and February 2024 that assessed maternal asthma during pregnancy (exposure) and child autism (outcome). Databases searched included MEDLINE, CINAHL, EMBASE, and PsycINFO. Of the 350 potential studies, 19 met the inclusion criteria (2,530,716 participants; 73,065 autistic participants). Quality was assessed with the Newcastle–Ottawa Scale. Meta-analyses using proportions and odds ratios were conducted using the Mantel–Haenszel method with a random-effects model. Compared to women without asthma, there was an increased odds of child autism with any history of maternal asthma (OR = 1.32; 95% CI = 1.21, 1.44; I2 = 61%, n = 14), with current asthma during pregnancy (OR = 1.23; 95% CI = 1.12, 1.35; I2 = 35%, n = 10) and with medication use during pregnancy (OR = 1.48; 95% CI = 1.30, 1.68; I2 = 0%, n = 3). However, when women with asthma who used asthma medication were compared to those with asthma who did not use medication, there were no increased odds for child autism (OR = 1.07; 95% CI = 0.89, 1.27; I2 = 34%, n = 2). Maternal asthma is associated with an increased odds of child autism. Future studies should consider neurodivergence in the parents, the severity of asthma, and the effectiveness of prescribed medication in managing the mother's asthma to improve our understanding of this association.
期刊介绍:
AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.