自闭症谱系障碍中外祖父母的年龄、种族和民族:加州多代研究。

IF 5.6 2区 医学 Q1 BEHAVIORAL SCIENCES
Autism Research Pub Date : 2025-06-20 DOI:10.1002/aur.70074
Ting Chow, Qi Meng, Jingyuan Xiao, Karl O'Sharkey, Zeyan Liew, Beate Ritz
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引用次数: 0

摘要

我们调查了外祖父母年龄与孙辈自闭症谱系障碍(ASD)之间的关系,探讨了种族/民族之间的差异。在一项多代加利福尼亚出生队列研究中,包括1,743,998和1,630,722对母子(分别有27,975和25,816例ASD病例),我们根据祖母和祖父在女儿出生时的年龄检查了ASD风险。采用Logistic回归获得优势比(ORs)和95% ci。白人祖母的孙辈患ASD的几率更高(OR, 1.14;95% CI, 1.08-1.20)和祖父(OR, 1.18;95% CI, 1.11-1.25),与25-29岁的对照相比,年龄更小(18-24岁)的黑人祖母与年龄更小的黑人祖母之间存在负相关(OR, 0.85;95% ci, 0.78-0.94)。在年龄较大(35-55岁)时,西班牙裔祖母患ASD的风险更高(OR, 1.13;95% CI, 1.06-1.21)和西班牙裔(OR, 1.12;95% CI, 1.06-1.18)和黑人祖父(OR, 1.18;95% ci, 1.05-1.32)。在几个种族/民族的年长祖父母中,孙辈患ASD的风险更高,但在最年轻的祖父母中,只有白人的风险更高。种族/民族的差异可能意味着不同的机制在年轻和年长的祖父母身上起作用。我们需要研究生物学以及社会、职业和环境因素对ASD妊娠年龄的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study

Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study

We investigated associations between maternal grandparents' age and autism spectrum disorders (ASD) in grandchildren, exploring differences by race/ethnicity. In a multigenerational California birth cohort study including 1,743,998 and 1,630,722 mother–child pairs (with 27,975 and 25,816 ASD cases, respectively), we examined ASD risk by grandmother's and grandfather's age at the time when their daughter was born. Logistic regression was used to obtain odds ratios (ORs) and 95% CIs. The odds of ASD in grandchildren were higher among White grandmothers (OR, 1.14; 95% CI, 1.08–1.20) and grandfathers (OR, 1.18; 95% CI, 1.11–1.25) who had daughters at younger ages (18–24 years) compared to the 25–29 year reference, while inverse associations were observed for younger Black grandmothers (OR, 0.85; 95% CI, 0.78–0.94). At older ages (35–55 years), ASD risks were higher among Hispanic grandmothers (OR, 1.13; 95% CI, 1.06–1.21) and Hispanic (OR, 1.12; 95% CI, 1.06–1.18) and Black grandfathers (OR, 1.18; 95% CI, 1.05–1.32). The risk of ASD in grandchildren was higher among older grandparents of several races/ethnicities but among the youngest grandparents only among those of White race. Differences by race/ethnicity may imply different mechanisms operating in younger and older grandparents. Studies exploring the contributions of biological as well as social, occupational, and environmental factors on the influence of age at pregnancy with ASD are needed.

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来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
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