蜂毒对患癌雌性小鼠肾脏损伤的保护作用。

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-06-01 DOI:10.31557/APJCP.2025.26.6.2233

Mohanad Salam Hussein, Shahad Falah Abass, Ahmed Flayyih Hasan, Ali G Al-Dulimi, Hany M El-Wahsh

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引用次数: 0

摘要

背景：癌症是一种可怕的疾病，对人们的个人、社会、经济生活以及医疗保健都有巨大的负面影响。本研究旨在探讨蜜蜂（Apis mellifera， A.M.）对小鼠埃利希腹水癌（Ehrlich as腹水癌，EAC）肾毒性及组织损伤的降低作用。方法：将40只雌性瑞士白化小鼠随机分为4组(G1组，对照组；G2,点;G3, EAC;G4, EAC+ A.M.)。结果：目前的研究结果显示EAC引起肾组织损伤，血清尿素、肌酐、钾和氯离子水平升高。与正常对照组相比，它们还导致血液中钠离子和钙离子水平显著下降。此外，EAC引起肾小球和肾小管的多种病理改变，包括肾小球轻度收缩、明显的细胞浸润、明显的肾损伤和明显的肾组织降解。当EAC与A.M. （EAC+ A.M.）治疗时，与单独使用EAC相比，肾脏结构和功能得到改善。血清尿素、肌酐、钾、氯离子水平降低，钠、钙离子水平升高。结论：am对EAC细胞的肾毒性有一定的保护作用。

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Protective Role of Bee Venom (Apis mellifera) Against Kidney Damage in Female Mice with Cancer.

Background: Cancer is a dreadful disease that has a huge, negative impact on people's personal, social, and financial lives, as well as their healthcare. The purpose of our study is to evaluate the capability of Apis mellifera (A.M.), to reduce the renal toxicity and tissue damage caused by the Ehrlich ascites carcinoma (EAC) in mice.

Methods: A total of forty female Swiss albino mice were divided evenly among four groups (G1, control; G2, A.M.; G3, EAC; and G4, EAC+ A.M.).

Results: The current results revealed that EAC caused renal tissue damage, and increase in the serum urea, creatinine, potassium, and chloride ion levels. They also caused a significant decrease in the levels of sodium and calcium ions in the blood, as compared to the normal control. Furthermore, EAC caused a variety of pathological alterations in the glomeruli and renal tubules, including mild glomerular shrinkage, notable cellular infiltration, marked renal injury, and marked renal tissue degradation. When EAC was treated with A.M. (EAC+ A.M.), the kidney structure and function improved, in comparison to the use of EAC alone. The serum urea, creatinine, potassium, and chloride ion levels decreased, but the sodium and calcium ion levels increased.

Conclusion: It was possible to conclude that A.M. could shield the kidneys from renal toxicity caused by the EAC cells.

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.