使用高分辨率磁共振成像表征前后循环卒中。

IF 3.7 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology Pub Date : 2025-06-19 DOI:10.1016/j.slast.2025.100319

Hongshan Chu , Shibo Dong , Yuan Zhang , Hongyu Hao , Ruisheng Duan , Xing Xing , Nan Yin , Jin An , Ya Gao , Xiangjian Xiao

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引用次数: 0

摘要

背景与目的：高分辨率磁共振成像（HR-MRI）越来越多地用于颅内动脉粥样硬化（ICAS）的评估。前循环卒中（ACS）和后循环卒中（PCS）的风险不同，了解影响这些差异的因素对更好的临床管理很重要。本研究利用HR-MRI研究临床危险因素对ACS和PCS的ICAS特征的影响，重点关注动脉重塑模式。方法：本回顾性横断面研究采用高分辨率磁共振成像技术研究前后循环卒中（ACS和PCS）斑块特征和重塑模式的差异。在2021年1月至2022年8月期间连续接受HR-MRI检查的急性缺血性卒中或短暂性脑缺血发作（TIA）患者入组。我们比较了ACS和PCS病例，分析了临床和影像学特征，并检查了与动脉重塑模式相关的因素。结果：208例患者中，ACS 123例，PCS 85例。PCS与糖尿病（P = 0.036）和正重构（P = 0.01）显著相关。ACS和PCS患者在HbA1c、纤维蛋白原水平和斑块增强方面存在差异(P < 0.001；P = 0.033; = 0.03页)。多变量分析发现吸烟(P = 0.048；OR: 1.96, 95% CI: 1.01-3.81)和尿酸水平(P = 0.022；OR: 0.996, 95% CI: 0.993-0.999)是与非阳性重塑相关的独立因素。结论：HR-MRI显示ACS和PCS的危险因素和斑块特征有显著差异，吸烟和尿酸水平与非阳性重构相关。这些发现强调了HR-MRI在识别斑块易感性和指导临床干预方面的重要性。

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Characterizing anterior and posterior circulation strokes using high-resolution magnetic resonance imaging

Background and Purpose

High-resolution magnetic resonance imaging (HR-MRI) is increasingly used to assess intracranial atherosclerosis (ICAS). The risks for anterior circulation stroke (ACS) and posterior circulation stroke (PCS) differ, and understanding the factors influencing these differences is important for better clinical management. This study investigates the impact of clinical risk factors on ICAS features in ACS and PCS using HR-MRI, focusing on arterial remodeling patterns.

Methods

This retrospective, cross-sectional study uses HR-MRI to investigate the differences in plaque characteristics and remodeling patterns between anterior and posterior circulation strokes (ACS and PCS). Consecutive patients with acute ischemic stroke or transient ischemic attack (TIA) who received HR-MRI from January 2021 to August 2022 were enrolled. We compared ACS and PCS cases, analyzed clinical and radiological features, and examined factors associated with arterial remodeling patterns.

Results

Of 208 patients, 123 had ACS, and 85 had PCS. PCS was significantly associated with diabetes (P = 0.036) and positive remodeling (P = 0.01). Differences in HbA1c, fibrinogen levels, and plaque enhancement were observed between ACS and PCS (P < 0.001; P = 0.033; P = 0.03). Multivariable analysis identified smoking (P = 0.048; OR: 1.96, 95 % CI: 1.01–3.81) and uric acid levels (P = 0.022; OR: 0.996, 95 % CI: 0.993–0.999) as independent factors associated with non-positive remodeling.

Conclusions

HR-MRI reveals significant differences in risk factors and plaque characteristics between ACS and PCS, with smoking and uric acid levels associated with non-positive remodeling. These findings highlight the importance of HR-MRI in identifying plaque vulnerability and guiding clinical interventions.

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来源期刊

SLAS Technology Computer Science-Computer Science Applications

CiteScore

6.30

自引率

7.40%

发文量

审稿时长

106 days

期刊介绍： SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.