介绍非编码rna。

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-02-19 DOI:10.1016/bs.pmbts.2025.01.006

Charan Psvv, Adithya Joseph, Praveen Ebenezer, Vandana Sankar, Renuka Suravajhala, R Shyama Prasad Rao, Prashanth Suravajhala

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引用次数: 0

摘要

非编码rna （ncRNAs）是一组不编码蛋白质但在多种生物功能中发挥关键作用的rna，如基因调控、染色质重塑和其他细胞过程。两种主要的ncrna类型是小ncrna （sncrna，大小为21-34个核苷酸）和长ncrna （lncrna，大小为100 - 200个核苷酸），每种ncrna都有多个亚型。值得注意的是，ncRNAs占人类基因组rna的90%以上。探索ncrna对于理解细胞调控的复杂性以及作为生物标志物或治疗各种疾病（如癌症）的潜在治疗应用非常重要。在本章中，我们提供了ncrna及其在调控中的作用的要点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An introduction to non-coding RNAs.

Non-coding RNAs (ncRNAs) are a group of RNAs that do not encode proteins but play key roles in diverse biological functions such as gene regulation, chromatin remodeling, and other cellular processes. Two major types are small ncRNAs (sncRNAs, with a size of ∼21-34 nucleotides) and long ncRNAs (lncRNAs, size of>200 nucleotides), and each has multiple subtypes. Notably, ncRNAs constitute over 90 % of the RNAs from the human genome. Exploring ncRNAs is important to understand the complexities of cellular regulations and for potential therapeutic applications as biomarkers or therapies in various diseases such as cancer. In this chapter, we provide a gist of ncRNAs, their role in regulation.

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来源期刊

Progress in molecular biology and translational science 生物-生化与分子生物学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.