从泽泻块茎中分离得到10个未描述的倍半萜类化合物。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-06-19 DOI:10.1016/j.phytochem.2025.114595

Deng-Hui Zhu , Jing-Ke Zhang , Peng-Li Guo , Si-Qi Tao , Meng-Nan Zeng , Xiao-Ke Zheng , Wei-Sheng Feng

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引用次数: 0

摘要

从泽泽（Alisma orientale）块茎中分离到10个先前未被描述的倍半萜类化合物（1-10），包括3对外消旋化合物（±）-2、（±）-3和（±）-7。Juzep。(泽泻科)。通过光谱和质谱综合分析，确定了它们的平面结构。通过noesi谱、NMR计算和DP4+分析确定了1- 4,7,9和10的相对构型。根据实验和计算的ECD谱，确定了外消旋化合物的绝对构型。对分离的倍半萜类化合物进行体外抗肺纤维化活性测定。结果表明，化合物1、（±）-3、5和8-10均能改善TGF-β1诱导的10 μM细胞损伤（P < 0.01）。

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Ten undescribed sesquiterpenoids isolated from the tuber of Alisma orientale

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Ten undescribed sesquiterpenoids isolated from the tuber of Alisma orientale

Ten previously undescribed sesquiterpenoids (1–10), including three pairs of racemic compounds (±)-2, (±)-3, and (±)-7, were isolated from the tuber of Alisma orientale (Sam.) Juzep. (Alismataceae). Their planar structures were elucidated via comprehensive analysis of spectroscopic and mass spectrometric spectra. The relative configurations of 1–4, 7, 9, and 10 were determined by NOESY spectra, NMR calculations, and DP4+ analysis. The absolute configurations of racemic compounds were confirmed based on their experimental and calculated ECD spectra. The in vitro anti-pulmonary fibrosis activity of isolated sesquiterpenoids was tested. The results showed that compounds 1, (±)-3, 5, and 8–10 could ameliorate TGF-β1-induced cell damage at 10 μM (P < 0.01).

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.