半夏茎叶中的去甲倍半萜。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-06-19 DOI:10.1016/j.phytochem.2025.114590

Xu Chen , Yan-gang Cao , Fang-Ge Chi , Yan-ling Liu , Kai-li Ye , Xiao-ke Zheng , Wei-sheng Feng

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引用次数: 0

摘要

对半夏（Pinellia pedatisecta Schott）茎叶的化学研究发现了40种降倍半萜，包括11种未描述的化合物（1-6、10-13和23）和29种已知的类似物。它们的结构通过详细的光谱和比较文献数据分析得以阐明。利用Mo2(OAc)4诱导ECD光谱分析、DP4+和ECD分析确定未描述菌株的绝对构型。此外，生物活性评价结果表明，组分3-6、8-10、12、14、15、17-19、21-22、25-29、33和39均能显著改善a β25-35诱导的PC-12细胞损伤。网络药理学结果显示STAT3、NFKB1、HIF1A、EGFR、CASP3是化合物3-6、10、12抗AD的相关靶点，Ras、PI3K-Akt、MAPK是潜在的信号通路。本研究为阿尔茨海默病的治疗提供了实验基础，未来我们将进一步在细胞和小鼠中探索机制，寻找准确的靶点和通路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Norsesquiterpenes from the stems and leaves of Pinellia pedatisecta Schott

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Norsesquiterpenes from the stems and leaves of Pinellia pedatisecta Schott

A chemical investigation of the stems and leaves of Pinellia pedatisecta Schott afforded forty norsesquiterpenes, including eleven undescribed compounds (1−6, 10−13, and 23) and twenty-nine known analogues. Their structures were elucidated using detailed spectroscopic and comparative literature data analysis. The Mo₂(OAc)₄-induced ECD spectral analysis, DP4+ and ECD analysis were used to determine the absolute configuration of undescribed isolates. In addition, the results of the bioactivity evaluation indicated that components 3−6, 8−10, 12, 14, 15, 17−19, 21−22, 25−29, 33, and 39 significantly improved Aβ_25-35-induced PC-12 cell damage. The network pharmacology results showed that STAT3, NFKB1, HIF1A, EGFR, CASP3 were the correlated targets of compounds 3−6, 10, and 12 against AD, with Ras, PI3K-Akt, and MAPK as the potential signaling pathways. This study provided experimental basis for the treatment of Alzheimer's disease and we will further explore mechanisms in cells and mice to find accurate targets and pathways in the future.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.