Fergus K O'Connor, Dongyi Chen, Pramod Sharma, Julie Adsett, Rita Hwang, Llion Roberts, Aaron Bach, Menaka Louis, Norman Morris
{"title":"心衰患者对坐立和6分钟步行试验的生理反应：一项随机试验","authors":"Fergus K O'Connor, Dongyi Chen, Pramod Sharma, Julie Adsett, Rita Hwang, Llion Roberts, Aaron Bach, Menaka Louis, Norman Morris","doi":"10.1016/j.hlc.2025.03.002","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Short-duration sit-to-stand tests are utilised in rehabilitation settings to alleviate logistical challenges associated with the six-minute walk test (6MWT). We assessed the utility of the 30-second sit-to-stand (30-STST) and 60-second sit-to-stand (60-STST) tests as surrogate measures of the 6MWT.</p><p><strong>Method: </strong>On separate days, 16 male participants (71 [7] years) with stable heart failure with reduced ejection fraction (36.9 [4.9] %) completed two 6MWT and the 30-STST and 60-STST. Pulmonary gas exchange (oxygen consumption, carbon dioxide production [V˙CO<sub>2</sub>], ventilation [V˙<sub>E</sub>], respiratory exchange ratio, ventilatory equivalent for CO<sub>2</sub> [V˙<sub>E</sub>/V˙CO<sub>2</sub>] and partial pressure of end-tidal CO<sub>2</sub> [P<sub>ET</sub>CO<sub>2</sub>]) was measured using a portable metabolic system. Non-invasive haemodynamics (cardiac output, stroke volume, arteriovenous oxygen difference) were measured using impedance cardiography. Mean arterial pressure, heart rate, oxygen saturation and dyspnoea (0-10 scale, arbitrary units) were also monitored. Mixed-effects models (Bonferroni corrected) accounting for time (pre-exercise rest, end-exercise) and test (6MWT, 30-STST, and 60-STST) were used to assess the relation between results observed during each testing modality.</p><p><strong>Results: </strong>While P<sub>ET</sub>CO<sub>2</sub> (mean difference [95% confidence interval], -4.9 [-8.9 to -0.8] mmHg), and dyspnoea (1 [0-2] arbitrary units) differed between the 6MWT and 60-STST, no other differences were observed between these tests. In contrast, oxygen consumption (-0.5 [-0.6 to -0.3] L.min<sup>-1</sup>), V˙CO<sub>2</sub> (-0.5 [-0.7 to -0.4] L.min<sup>-1</sup>), V˙<sub>E</sub> (-18.3 [-26.0 to -10.0] L.min<sup>-1</sup>), P<sub>ET</sub>CO<sub>2</sub> (-5.1 [-9.6 to -0.7] mmHg), cardiac output (-2.4 [-4.9 to -0.3] L.min<sup>-1</sup>), heart rate (-20 [-33 to -7] beats/min) differed between the 6MWT and the 30-STST, however, no other differences were observed between the 6MWT and the 30-STST.</p><p><strong>Conclusions: </strong>Cardiopulmonary, non-invasive haemodynamic and dyspnoea responses differed between the 30-STST and the 6MWT. However, the lack of test-specific differences between the 6MWT and the 60-STST highlights the strong physiological stimulus elicited by this short-duration test modality. The 60-STST has promising utility as a functional measure of heart and lung capacity within cardiac rehabilitation programs.</p>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Physiological Responses to Sit-to-Stand and Six-Minute Walk Tests in Heart Failure: A Randomised Trial.\",\"authors\":\"Fergus K O'Connor, Dongyi Chen, Pramod Sharma, Julie Adsett, Rita Hwang, Llion Roberts, Aaron Bach, Menaka Louis, Norman Morris\",\"doi\":\"10.1016/j.hlc.2025.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Short-duration sit-to-stand tests are utilised in rehabilitation settings to alleviate logistical challenges associated with the six-minute walk test (6MWT). We assessed the utility of the 30-second sit-to-stand (30-STST) and 60-second sit-to-stand (60-STST) tests as surrogate measures of the 6MWT.</p><p><strong>Method: </strong>On separate days, 16 male participants (71 [7] years) with stable heart failure with reduced ejection fraction (36.9 [4.9] %) completed two 6MWT and the 30-STST and 60-STST. Pulmonary gas exchange (oxygen consumption, carbon dioxide production [V˙CO<sub>2</sub>], ventilation [V˙<sub>E</sub>], respiratory exchange ratio, ventilatory equivalent for CO<sub>2</sub> [V˙<sub>E</sub>/V˙CO<sub>2</sub>] and partial pressure of end-tidal CO<sub>2</sub> [P<sub>ET</sub>CO<sub>2</sub>]) was measured using a portable metabolic system. Non-invasive haemodynamics (cardiac output, stroke volume, arteriovenous oxygen difference) were measured using impedance cardiography. Mean arterial pressure, heart rate, oxygen saturation and dyspnoea (0-10 scale, arbitrary units) were also monitored. Mixed-effects models (Bonferroni corrected) accounting for time (pre-exercise rest, end-exercise) and test (6MWT, 30-STST, and 60-STST) were used to assess the relation between results observed during each testing modality.</p><p><strong>Results: </strong>While P<sub>ET</sub>CO<sub>2</sub> (mean difference [95% confidence interval], -4.9 [-8.9 to -0.8] mmHg), and dyspnoea (1 [0-2] arbitrary units) differed between the 6MWT and 60-STST, no other differences were observed between these tests. In contrast, oxygen consumption (-0.5 [-0.6 to -0.3] L.min<sup>-1</sup>), V˙CO<sub>2</sub> (-0.5 [-0.7 to -0.4] L.min<sup>-1</sup>), V˙<sub>E</sub> (-18.3 [-26.0 to -10.0] L.min<sup>-1</sup>), P<sub>ET</sub>CO<sub>2</sub> (-5.1 [-9.6 to -0.7] mmHg), cardiac output (-2.4 [-4.9 to -0.3] L.min<sup>-1</sup>), heart rate (-20 [-33 to -7] beats/min) differed between the 6MWT and the 30-STST, however, no other differences were observed between the 6MWT and the 30-STST.</p><p><strong>Conclusions: </strong>Cardiopulmonary, non-invasive haemodynamic and dyspnoea responses differed between the 30-STST and the 6MWT. However, the lack of test-specific differences between the 6MWT and the 60-STST highlights the strong physiological stimulus elicited by this short-duration test modality. The 60-STST has promising utility as a functional measure of heart and lung capacity within cardiac rehabilitation programs.</p>\",\"PeriodicalId\":13000,\"journal\":{\"name\":\"Heart, Lung and Circulation\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Heart, Lung and Circulation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.hlc.2025.03.002\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart, Lung and Circulation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.hlc.2025.03.002","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Physiological Responses to Sit-to-Stand and Six-Minute Walk Tests in Heart Failure: A Randomised Trial.
Background: Short-duration sit-to-stand tests are utilised in rehabilitation settings to alleviate logistical challenges associated with the six-minute walk test (6MWT). We assessed the utility of the 30-second sit-to-stand (30-STST) and 60-second sit-to-stand (60-STST) tests as surrogate measures of the 6MWT.
Method: On separate days, 16 male participants (71 [7] years) with stable heart failure with reduced ejection fraction (36.9 [4.9] %) completed two 6MWT and the 30-STST and 60-STST. Pulmonary gas exchange (oxygen consumption, carbon dioxide production [V˙CO2], ventilation [V˙E], respiratory exchange ratio, ventilatory equivalent for CO2 [V˙E/V˙CO2] and partial pressure of end-tidal CO2 [PETCO2]) was measured using a portable metabolic system. Non-invasive haemodynamics (cardiac output, stroke volume, arteriovenous oxygen difference) were measured using impedance cardiography. Mean arterial pressure, heart rate, oxygen saturation and dyspnoea (0-10 scale, arbitrary units) were also monitored. Mixed-effects models (Bonferroni corrected) accounting for time (pre-exercise rest, end-exercise) and test (6MWT, 30-STST, and 60-STST) were used to assess the relation between results observed during each testing modality.
Results: While PETCO2 (mean difference [95% confidence interval], -4.9 [-8.9 to -0.8] mmHg), and dyspnoea (1 [0-2] arbitrary units) differed between the 6MWT and 60-STST, no other differences were observed between these tests. In contrast, oxygen consumption (-0.5 [-0.6 to -0.3] L.min-1), V˙CO2 (-0.5 [-0.7 to -0.4] L.min-1), V˙E (-18.3 [-26.0 to -10.0] L.min-1), PETCO2 (-5.1 [-9.6 to -0.7] mmHg), cardiac output (-2.4 [-4.9 to -0.3] L.min-1), heart rate (-20 [-33 to -7] beats/min) differed between the 6MWT and the 30-STST, however, no other differences were observed between the 6MWT and the 30-STST.
Conclusions: Cardiopulmonary, non-invasive haemodynamic and dyspnoea responses differed between the 30-STST and the 6MWT. However, the lack of test-specific differences between the 6MWT and the 60-STST highlights the strong physiological stimulus elicited by this short-duration test modality. The 60-STST has promising utility as a functional measure of heart and lung capacity within cardiac rehabilitation programs.
期刊介绍：
Heart, Lung and Circulation publishes articles integrating clinical and research activities in the fields of basic cardiovascular science, clinical cardiology and cardiac surgery, with a focus on emerging issues in cardiovascular disease. The journal promotes multidisciplinary dialogue between cardiologists, cardiothoracic surgeons, cardio-pulmonary physicians and cardiovascular scientists.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
