基因和环境对青春期早期ReHo和fALFF的影响在不同的大脑区域有所不同。

IF 2.9 2区 医学 Q2 NEUROSCIENCES
Lachlan T Strike, Katie L McMahon, Sarah E Medland, Greig I de Zubicaray
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引用次数: 0

摘要

遗传和环境对脑功能影响的研究通常集中在脑区域之间的联系上。另一种不同的尚未探索的方法是检查局部大脑区域的活动。我们研究了基因和环境效应对局部脑功能的两个具体指标的影响:区域均匀性和低频波动的分数幅度。参与者从青春期双胞胎样本中抽取两次(平均年龄11.5岁和13.2岁,n = 278和248)。结果表明,遗传和环境因素影响了几乎所有210个皮质区域的大脑功能。此外,影响第1波(9至14年)的区域均匀性和低频波动值的分数幅值的遗传和共同环境因素也影响许多地区第2波(10至16年)的值。然而,遗传和常见环境因素的影响在大脑皮层中是不同的,在不同的区域表现出不同的模式。此外,我们发现了新的(即独立的)遗传和环境对第二波大脑活动的影响,同样具有区域模式。探索性分析发现,焦虑和抑郁症状与颞叶几个区域的局部大脑功能之间存在微弱关联。这些发现与其他静息状态功能MRI指标(即功能连接)的类似研究一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions.

Research on genetic and environmental influences on brain function generally focuses on connections between brain areas. A different yet unexplored approach is to examine activity within local brain regions. We investigated the influence of genes and environmental effects on two specific measures of local brain function: regional homogeneity and fractional amplitude of low-frequency fluctuations. Participants were drawn from a sample of adolescent twins on two occasions (mean ages 11.5 and 13.2 yr, n = 278 and 248). Results showed that genetic and environmental factors influenced brain function in almost all 210 cortical regions examined. Moreover, genetic and common environmental factors influencing regional homogeneity and fractional amplitude of low-frequency fluctuation values at wave 1 (9 to 14 yr) also influenced values at wave 2 (10 to 16 yr) for many regions. However, the influence of genetic and common environmental factors varied across the cortex, exhibiting different patterns in different regions. Furthermore, we found new (ie independent) genetic and environmental influences on brain activity at wave 2, again with regional patterns. Exploratory analyses found weak associations between anxiety and depressive symptoms and local brain function in several regions of the temporal lobe. These findings are consistent with similar studies of other resting-state functional MRI metrics (ie functional connectivity).

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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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