Xiaojing Leng, Yang Yang, Tao Jiang, Jun Zheng, Liang Zhang, Ju Huang, Han Xu, Mingxiao Fang, Xingsheng Li, Zhigang Wang, Min Ge, Han Lin
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An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte (Adv. Healthcare Mater. 16/2025)
Metabolic Nanoblocker for Cancer Therapy
Tumor cells rely heavily on continuously generating energy for proliferation and metastasis. In article 2405174, Xingsheng Li, Zhigang Wang, Min Ge, Han Lin, and co-workers develop a CD44 receptor-targeted hyaluronic acid energy metabolism nanoblocker. This emerging strategy involves depleting tumor cell energy through the inhibition of basal respiration (OXPHOS/glycolysis) and extra respiration, while also synergistically enhancing effector immune cells to maintain systemic anti-tumor immune effects.
期刊介绍:
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.