一种能量代谢纳米阻断剂用于切断肿瘤细胞呼吸和抑制细胞毒性T淋巴细胞的线粒体劫持(Adv. Healthcare Mater. 16/2025)

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Xiaojing Leng, Yang Yang, Tao Jiang, Jun Zheng, Liang Zhang, Ju Huang, Han Xu, Mingxiao Fang, Xingsheng Li, Zhigang Wang, Min Ge, Han Lin
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引用次数: 0

摘要

肿瘤细胞的增殖和转移在很大程度上依赖于持续产生能量。在文章2405174中,李兴生,王志刚,葛敏,林晗等人开发了一种靶向CD44受体的透明质酸能量代谢纳米阻断剂。这种新出现的策略包括通过抑制基础呼吸(OXPHOS/糖酵解)和额外呼吸来消耗肿瘤细胞的能量,同时也协同增强效应免疫细胞以维持全身抗肿瘤免疫作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte (Adv. Healthcare Mater. 16/2025)

An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte (Adv. Healthcare Mater. 16/2025)

Metabolic Nanoblocker for Cancer Therapy

Tumor cells rely heavily on continuously generating energy for proliferation and metastasis. In article 2405174, Xingsheng Li, Zhigang Wang, Min Ge, Han Lin, and co-workers develop a CD44 receptor-targeted hyaluronic acid energy metabolism nanoblocker. This emerging strategy involves depleting tumor cell energy through the inhibition of basal respiration (OXPHOS/glycolysis) and extra respiration, while also synergistically enhancing effector immune cells to maintain systemic anti-tumor immune effects.

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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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