{"title":"内页封面：细菌iii型铜酶中亚硝基形成活性选择器的鉴定（新）。化学26/2025)","authors":"Hoa Le Xuan, Felix Panis, Annette Rompel","doi":"10.1002/ange.202512251","DOIUrl":null,"url":null,"abstract":"<p>Enzyme specificity defines function: aminophenol oxidase uniquely converts aminophenols into nitrosophenols, whereas tyrosinase transforms them into quinone imines. This distinction is governed by a key amino acid near the copper(A) active site. In their Research Article (e202501560), Annette Rompel et al. demonstrated that a single amino acid exchange—swapping asparagine in SgGriF with isoleucine in SzTYR—can effectively invert the enzymes’ functions.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 26","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202512251","citationCount":"0","resultStr":"{\"title\":\"Inside Front Cover: Identification of an Activity Selector for the Nitroso-Forming Activity in Bacterial Type-III Copper Enzymes (Angew. Chem. 26/2025)\",\"authors\":\"Hoa Le Xuan, Felix Panis, Annette Rompel\",\"doi\":\"10.1002/ange.202512251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Enzyme specificity defines function: aminophenol oxidase uniquely converts aminophenols into nitrosophenols, whereas tyrosinase transforms them into quinone imines. This distinction is governed by a key amino acid near the copper(A) active site. In their Research Article (e202501560), Annette Rompel et al. demonstrated that a single amino acid exchange—swapping asparagine in SgGriF with isoleucine in SzTYR—can effectively invert the enzymes’ functions.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":7803,\"journal\":{\"name\":\"Angewandte Chemie\",\"volume\":\"137 26\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202512251\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Angewandte Chemie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ange.202512251\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ange.202512251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inside Front Cover: Identification of an Activity Selector for the Nitroso-Forming Activity in Bacterial Type-III Copper Enzymes (Angew. Chem. 26/2025)
Enzyme specificity defines function: aminophenol oxidase uniquely converts aminophenols into nitrosophenols, whereas tyrosinase transforms them into quinone imines. This distinction is governed by a key amino acid near the copper(A) active site. In their Research Article (e202501560), Annette Rompel et al. demonstrated that a single amino acid exchange—swapping asparagine in SgGriF with isoleucine in SzTYR—can effectively invert the enzymes’ functions.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
