睡眠健康状况不佳与阿尔茨海默病结构神经成像生物标志物之间的关系

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-06-22 DOI:10.1002/alz.70364

Emma Nolan, Yunyi Sun, Hui Shi, Derek Archer, Arden Perry, Kimberly Pechman, Niranjana Shashikumar, Bennett Landman, Marissa Gogniat, Dandan Liu, Panpan Zhang, Timothy J. Hohman, Angela L. Jefferson, Kelsie M. Full

{"title":"睡眠健康状况不佳与阿尔茨海默病结构神经成像生物标志物之间的关系","authors":"Emma Nolan, Yunyi Sun, Hui Shi, Derek Archer, Arden Perry, Kimberly Pechman, Niranjana Shashikumar, Bennett Landman, Marissa Gogniat, Dandan Liu, Panpan Zhang, Timothy J. Hohman, Angela L. Jefferson, Kelsie M. Full","doi":"10.1002/alz.70364","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Poor sleep may be a risk factor for neurodegeneration and Alzheimer's disease (AD). Few studies have examined objectively measured sleep with structural neuroimaging measures.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Vanderbilt Memory and Aging Project participants (<i>N</i> = 407; median age: 70 years) wore ActiGraph accelerometers for 10 days to estimate sleep regularity, timing, efficiency, duration, wake-after-sleep onset, and awakening length. Volume in brain regions of interest (ROIs) and AD signatures were quantified using 3T brain magnetic resonance imaging (MRI). Cross-sectional linear regression models were adjusted for sociodemographic and lifestyle factors, depression, cognitive status, and cardiovascular risk. ROI and McEvoy models were adjusted for total intracranial volume.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Greater sleep irregularity (<i>β</i><sub>Hippocampus </sub>= −0.12, <i>p</i> = 0.005; <i>β</i><sub>McEvoy </sub>= −0.07, <i>p</i> = 0.024) and longer awakening length (<i>β</i><sub>Hippocampus </sub>= −0.11, <i>p</i> = 0.009; <i>β</i><sub>Parietal </sub>= −0.08, <i>p</i> = 0.012) were associated with smaller volumes in ROIs related to AD.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>More irregular and fragmented sleep was associated with smaller volume in ROIs vulnerable to AD, indicating a potential link between poor sleep and neurodegeneration.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Associations between sleep and brain health are poorly understood.</li>\n \n <li>Gray matter atrophy by irregular sleep may imply Alzheimer's disease (AD) decline.</li>\n \n <li>Increased sleep irregularity is associated with smaller brain region volume.</li>\n \n <li>Sleep disruption, estimated by awakening length, is linked to AD-related brain volume.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 6","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70364","citationCount":"0","resultStr":"{\"title\":\"The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers\",\"authors\":\"Emma Nolan, Yunyi Sun, Hui Shi, Derek Archer, Arden Perry, Kimberly Pechman, Niranjana Shashikumar, Bennett Landman, Marissa Gogniat, Dandan Liu, Panpan Zhang, Timothy J. Hohman, Angela L. Jefferson, Kelsie M. Full\",\"doi\":\"10.1002/alz.70364\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Poor sleep may be a risk factor for neurodegeneration and Alzheimer's disease (AD). Few studies have examined objectively measured sleep with structural neuroimaging measures.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>Vanderbilt Memory and Aging Project participants (<i>N</i> = 407; median age: 70 years) wore ActiGraph accelerometers for 10 days to estimate sleep regularity, timing, efficiency, duration, wake-after-sleep onset, and awakening length. Volume in brain regions of interest (ROIs) and AD signatures were quantified using 3T brain magnetic resonance imaging (MRI). Cross-sectional linear regression models were adjusted for sociodemographic and lifestyle factors, depression, cognitive status, and cardiovascular risk. ROI and McEvoy models were adjusted for total intracranial volume.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Greater sleep irregularity (<i>β</i><sub>Hippocampus </sub>= −0.12, <i>p</i> = 0.005; <i>β</i><sub>McEvoy </sub>= −0.07, <i>p</i> = 0.024) and longer awakening length (<i>β</i><sub>Hippocampus </sub>= −0.11, <i>p</i> = 0.009; <i>β</i><sub>Parietal </sub>= −0.08, <i>p</i> = 0.012) were associated with smaller volumes in ROIs related to AD.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>More irregular and fragmented sleep was associated with smaller volume in ROIs vulnerable to AD, indicating a potential link between poor sleep and neurodegeneration.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Associations between sleep and brain health are poorly understood.</li>\\n \\n <li>Gray matter atrophy by irregular sleep may imply Alzheimer's disease (AD) decline.</li>\\n \\n <li>Increased sleep irregularity is associated with smaller brain region volume.</li>\\n \\n <li>Sleep disruption, estimated by awakening length, is linked to AD-related brain volume.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 6\",\"pages\":\"\"},\"PeriodicalIF\":13.0000,\"publicationDate\":\"2025-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70364\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/alz.70364\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70364","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

睡眠不足可能是神经变性和阿尔茨海默病（AD）的危险因素。很少有研究用结构神经成像测量客观地测量睡眠。方法范德比尔特记忆与衰老项目参与者(N = 407；中位年龄：70岁)佩戴ActiGraph加速计10天，以评估睡眠规律、时间、效率、持续时间、醒后觉醒时间和觉醒时间。使用3T脑磁共振成像（MRI）量化脑感兴趣区（roi）和AD特征的体积。横截面线性回归模型调整了社会人口统计学和生活方式因素、抑郁、认知状况和心血管风险。对ROI和McEvoy模型进行颅内总容积调整。结果：睡眠不规律加重(海马β = - 0.12, p = 0.005；βMcEvoy =−0.07,p = 0.024)和更长的觉醒长度(β海马=−0.11,p = 0.009；β顶叶=−0.08,p = 0.012)与AD相关的roi体积较小相关。更不规律和碎片化的睡眠与易患AD的roi体积较小相关，表明睡眠不良与神经变性之间存在潜在联系。人们对睡眠和大脑健康之间的关系知之甚少。不规律睡眠导致的灰质萎缩可能意味着阿尔茨海默病（AD）的下降。睡眠不规律增加与大脑区域体积变小有关。睡眠中断，通过觉醒时间估计，与ad相关的脑容量有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers

INTRODUCTION

Poor sleep may be a risk factor for neurodegeneration and Alzheimer's disease (AD). Few studies have examined objectively measured sleep with structural neuroimaging measures.

METHODS

Vanderbilt Memory and Aging Project participants (N = 407; median age: 70 years) wore ActiGraph accelerometers for 10 days to estimate sleep regularity, timing, efficiency, duration, wake-after-sleep onset, and awakening length. Volume in brain regions of interest (ROIs) and AD signatures were quantified using 3T brain magnetic resonance imaging (MRI). Cross-sectional linear regression models were adjusted for sociodemographic and lifestyle factors, depression, cognitive status, and cardiovascular risk. ROI and McEvoy models were adjusted for total intracranial volume.

RESULTS

Greater sleep irregularity (β_Hippocampus= −0.12, p = 0.005; β_McEvoy= −0.07, p = 0.024) and longer awakening length (β_Hippocampus= −0.11, p = 0.009; β_Parietal= −0.08, p = 0.012) were associated with smaller volumes in ROIs related to AD.

DISCUSSION

More irregular and fragmented sleep was associated with smaller volume in ROIs vulnerable to AD, indicating a potential link between poor sleep and neurodegeneration.

Highlights

Associations between sleep and brain health are poorly understood.
Gray matter atrophy by irregular sleep may imply Alzheimer's disease (AD) decline.
Increased sleep irregularity is associated with smaller brain region volume.
Sleep disruption, estimated by awakening length, is linked to AD-related brain volume.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.