在观察性研究中测量不同分位数种族影响的广义增强模型

IF 1.8 3区 生物学 Q4 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Lili Yue, Jiayue Zhang, Ping Yu, Gaorong Li
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引用次数: 0

摘要

在本文中,我们考虑在纵向数据的观察性研究中治疗效果在不同分位数的估计问题。研究动机来自NHLBI(国家心肺血液研究所)生长与健康研究(NGHS),这是一项纵向队列研究,旨在讨论种族对心血管危险因素的影响。由于真实倾向评分模型未知,采用非参数广义提升模型(GBM)方法获得倾向评分估计量。结合分位数回归和逆概率加权的思想,提出了一种基于gbm的分位数处理效果加权估计方法,并将其应用于NGHS数据中,衡量不同分位数的种族效应。结果表明,种族效应在不同的分位数水平上存在差异,可能不等于零。在不同的参数配置下,进行了一些仿真研究,与现有方法相比,评估了我们提出的估计方法的有效性和优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Generalized Boosted Models to Measure Racial Effects at Different Quantiles in Observational Studies

In this paper, we consider the estimation problem of treatment effect at different quantiles in observational studies with longitudinal data. The research motivation is from the NHLBI (National Heart, Lung, and Blood Institute) Growth and Health Study (NGHS), a longitudinal cohort study that aims to discuss the effects of race on cardiovascular risk factors. Because the true propensity score model is unknown, a nonparametric generalized boosted models (GBM) method is adopted to obtain the propensity score estimator. Combining the ideas of quantile regression and inverse probability weighting, a GBM-based quantile weighting estimation method is developed for the quantile treatment effect and applied in NGHS data to measure the racial effects at different quantiles. The results indicate that the racial effect varies with different quantile levels and may not equal to zero. Under various parameter configurations, some simulation studies are conducted to assess the effectiveness and advantages of our proposed estimation method compared with the existing approaches.

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来源期刊
Biometrical Journal
Biometrical Journal 生物-数学与计算生物学
CiteScore
3.20
自引率
5.90%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Biometrical Journal publishes papers on statistical methods and their applications in life sciences including medicine, environmental sciences and agriculture. Methodological developments should be motivated by an interesting and relevant problem from these areas. Ideally the manuscript should include a description of the problem and a section detailing the application of the new methodology to the problem. Case studies, review articles and letters to the editors are also welcome. Papers containing only extensive mathematical theory are not suitable for publication in Biometrical Journal.
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