An efficient synthesis of Indolo[3,2-c]coumarins by Pd-catalyzed intramolecular CH carbonylation

Indolo[3,2-c]coumarins, characterized by their distinctive fused heterocyclic architecture, demonstrate significant biological activities in natural settings. In this study, we report a Pd-catalyzed intramolecular CH carbonylation methodology for the synthesis of indolo[3,2-c]coumarins, and provide a straightforward approach for the total synthesis of natural product derivative and bioactive molecule of this class. This novel methodology provides a versatile platform for the comprehensive synthesis of indolo[3,2-c]coumarins.