前交叉韧带损伤并发关节接触引起软骨微损伤和软骨下骨硬化，导致膝关节骨关节炎

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage Pub Date : 2025-06-19 DOI:10.1016/j.joca.2025.06.007

Kei Takahata, Yu-Yang Lin, Benjamin Osipov, Kohei Arakawa, Saaya Enomoto, Blaine A. Christiansen, Takanori Kokubun

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引用次数: 0

摘要

前交叉韧带（ACL）损伤通过两个不同的过程引发创伤后骨关节炎（PTOA）： ACL损伤时软骨表面的初始直接接触损伤和ACL缺陷引起的继发性关节不稳定。利用已建立的压迫性acl破裂和一种新的非压迫性acl破裂小鼠模型，我们旨在揭示软骨压迫和关节不稳定对上睑下垂进展的个体影响。

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Concurrent joint contact in anterior cruciate ligament injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis

Anterior cruciate ligament (ACL) injury initiates post-traumatic osteoarthritis (PTOA) via two distinct processes: initial direct contact injury of the cartilage surface during ACL injury, and secondary joint instability due to the ACL deficiency. Using the well-established Compression-induced ACL-rupture and a novel Non-Compression ACL-rupture mice model, we aimed to reveal the individual effects of cartilage compression and joint instability on PTOA progression.

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来源期刊

Osteoarthritis and Cartilage 医学-风湿病学

CiteScore

11.70

自引率

7.10%

发文量

802

审稿时长

52 days

期刊介绍： Osteoarthritis and Cartilage is the official journal of the Osteoarthritis Research Society International. It is an international, multidisciplinary journal that disseminates information for the many kinds of specialists and practitioners concerned with osteoarthritis.