星形胶质细胞没有CLU它们会导致阿尔茨海默病。

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-06-18 DOI:10.1016/j.neuron.2025.05.011

Lucrezia Floro, Julia Tcw

引用次数: 0

摘要

Clusterin （CLU）是公认的阿尔茨海默病的遗传危险因素。在本期《神经元》杂志上，Lish等人1发现，由CLU风险等位基因引起的星形胶质细胞CLU水平降低，炎症加剧，突触功能降低，可能增加认知能力下降的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Astrocytes have no CLU they contribute to Alzheimer's disease.

Clusterin (CLU) is a recognized genetic risk factor for Alzheimer's disease. In this issue of Neuron, Lish et al.¹ found that lower CLU levels in astrocytes, caused by the CLU risk allele, heightened inflammation and reduced synaptic functions, potentially increasing risk for cognitive decline.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.