Jiakuan Tu, Yu Qiu, Yueting Zhang, Yang Yang, Yi Huang
{"title":"封闭精神病院抗精神病药物引起的脂质代谢异常的临床管理:挑战和综合策略。","authors":"Jiakuan Tu, Yu Qiu, Yueting Zhang, Yang Yang, Yi Huang","doi":"10.1186/s12944-025-02644-0","DOIUrl":null,"url":null,"abstract":"<p><p>In closed psychiatric settings, antipsychotic-induced lipid metabolism abnormalities pose significant clinical challenges. Constrained by limited patient mobility, fluctuating treatment adherence, and monotonous diets, traditional management struggles to adequately balance drug side effects with patient health needs. This study presents an integrated framework involving surveillance, intervention, and interdisciplinary collaboration. It includes a comprehensive \"admission-to-intervention\" monitoring system, low-glycemic diet combined with portion control, symptom-specific exercise programs, and strategies to improve treatment adherence. We establish quality metrics, including 100% baseline lipid testing for new admissions and ≥ 95% timely intervention rate for abnormalities. The patient-centered model reduces cardiovascular risks, improves patient outcomes, and offers a scalable approach for metabolic health management in resource-limited environments.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"220"},"PeriodicalIF":3.9000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181918/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical management of lipid metabolism abnormalities induced by antipsychotics in closed psychiatric settings: challenges and integrated strategies.\",\"authors\":\"Jiakuan Tu, Yu Qiu, Yueting Zhang, Yang Yang, Yi Huang\",\"doi\":\"10.1186/s12944-025-02644-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In closed psychiatric settings, antipsychotic-induced lipid metabolism abnormalities pose significant clinical challenges. Constrained by limited patient mobility, fluctuating treatment adherence, and monotonous diets, traditional management struggles to adequately balance drug side effects with patient health needs. This study presents an integrated framework involving surveillance, intervention, and interdisciplinary collaboration. It includes a comprehensive \\\"admission-to-intervention\\\" monitoring system, low-glycemic diet combined with portion control, symptom-specific exercise programs, and strategies to improve treatment adherence. We establish quality metrics, including 100% baseline lipid testing for new admissions and ≥ 95% timely intervention rate for abnormalities. The patient-centered model reduces cardiovascular risks, improves patient outcomes, and offers a scalable approach for metabolic health management in resource-limited environments.</p>\",\"PeriodicalId\":18073,\"journal\":{\"name\":\"Lipids in Health and Disease\",\"volume\":\"24 1\",\"pages\":\"220\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181918/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lipids in Health and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12944-025-02644-0\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-025-02644-0","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Clinical management of lipid metabolism abnormalities induced by antipsychotics in closed psychiatric settings: challenges and integrated strategies.
In closed psychiatric settings, antipsychotic-induced lipid metabolism abnormalities pose significant clinical challenges. Constrained by limited patient mobility, fluctuating treatment adherence, and monotonous diets, traditional management struggles to adequately balance drug side effects with patient health needs. This study presents an integrated framework involving surveillance, intervention, and interdisciplinary collaboration. It includes a comprehensive "admission-to-intervention" monitoring system, low-glycemic diet combined with portion control, symptom-specific exercise programs, and strategies to improve treatment adherence. We establish quality metrics, including 100% baseline lipid testing for new admissions and ≥ 95% timely intervention rate for abnormalities. The patient-centered model reduces cardiovascular risks, improves patient outcomes, and offers a scalable approach for metabolic health management in resource-limited environments.
期刊介绍:
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.