长期精神健康障碍和自杀行为与怀孕期间过度呕吐有关:来自英国生物银行的证据。

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Xiaona Na , Xijie Wang , Din Son Tan, Yufeng Tan, Celi Yang, Junhan Zhang, Yucheng Yang, John S. Ji, Ai Zhao
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引用次数: 0

摘要

背景:妊娠期过度呕吐(EVP)对妇女心理健康的长期影响尚不清楚。我们的目的是调查EVP与精神障碍和自杀相关行为风险的关系,以及不良妊娠结局(APOs)的潜在影响。方法:从英国生物银行研究中招募了267,925名基线时无精神障碍史的女性参与者。使用多变量Cox比例风险模型来估计EVP与精神障碍和自杀相关行为风险之间的关联。通过中介分析和网络分析来评估其他apo的作用。结果:初步分析共纳入267,925名参与者,平均基线年龄为57.0 岁。其中,409例(0.15% %)报告出现EVP。在中位(Q1, Q3) 13.6 年的随访期间,33,526(12. %)名参与者出现精神障碍,976(0.4 %)名参与者出现自杀相关行为。EVP与任何精神障碍(调整后的风险比[AHR]: 1.889, 95 % CI: 1.480, 2.412)、精神分裂症(AHR: 4.659, 95 % CI: 1.717, 12.645)、情绪障碍(AHR: 1.748, 95 % CI: 1.275, 2.397)和压力相关障碍(AHR: 2.088, 95 % CI: 1.481, 2.943)的高风险相关。妊娠丢失、妊娠糖尿病、血红蛋白水平和中性粒细胞与淋巴细胞的比例介导了这些关联。情绪障碍是将精神障碍与自杀相关行为联系起来的核心节点。结论:EVP与各种精神障碍的风险增加有关。对发生EVP的妇女进行长期的心理健康监测很重要,但需要进一步探索其潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-term mental health disorders and suicidal behaviors linked to excessive vomiting during pregnancy: Evidence from the UK biobank

Background

The long-term effect of excessive vomiting during pregnancy (EVP) on women's mental health remains unclear. We aimed to investigate the association of EVP with the risks of mental disorders and suicide-related behaviors, and the potential influence of adverse pregnancy outcomes (APOs).

Method

267,925 female participants without a prior history of mental disorders at baseline were recruited from the UK Biobank Study. Multivariable Cox proportional hazards models were used to estimate the associations between EVP and the risk of mental disorders and suicide-related behaviors. Mediation and network analyses were conducted to assess the role of other APOs.

Results

A total of 267,925 participants with a mean baseline age of 57.0 years were included in the primary analysis. Of these, 409 (0.15 %) reported experiencing EVP. During a median (Q1, Q3) follow-up time of 13.6 years, 33,526 (12.5 %) participants developed mental disorders, and 976 (0.4 %) experienced suicide-related behavior. EVP was associated with a higher risk of any mental disorders (adjusted Hazard Ratio [AHR]: 1.889, 95 % CI: 1.480, 2.412), Schizophrenia (AHR: 4.659, 95 % CI: 1.717, 12.645), mood disorders (AHR: 1.748, 95 % CI: 1.275, 2.397), and stress-related disorders (AHR: 2.088, 95 % CI: 1.481, 2.943). Pregnancy loss, gestational diabetes, hemoglobin levels, and the neutrophil-to-lymphocyte ratio mediate these associations. Mood disorders was a core node linking mental disorders to suicide-related behaviors.

Conclusions

EVP is associated with an increased risk of various mental disorders. Long-term mental health surveillance in women experiencing EVP is important, while further exploration on the underlying mechanism is required.
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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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