Xiaona Na , Xijie Wang , Din Son Tan, Yufeng Tan, Celi Yang, Junhan Zhang, Yucheng Yang, John S. Ji, Ai Zhao
{"title":"长期精神健康障碍和自杀行为与怀孕期间过度呕吐有关:来自英国生物银行的证据。","authors":"Xiaona Na , Xijie Wang , Din Son Tan, Yufeng Tan, Celi Yang, Junhan Zhang, Yucheng Yang, John S. Ji, Ai Zhao","doi":"10.1016/j.jad.2025.119706","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The long-term effect of excessive vomiting during pregnancy (EVP) on women's mental health remains unclear. We aimed to investigate the association of EVP with the risks of mental disorders and suicide-related behaviors, and the potential influence of adverse pregnancy outcomes (APOs).</div></div><div><h3>Method</h3><div>267,925 female participants without a prior history of mental disorders at baseline were recruited from the UK Biobank Study. Multivariable Cox proportional hazards models were used to estimate the associations between EVP and the risk of mental disorders and suicide-related behaviors. Mediation and network analyses were conducted to assess the role of other APOs.</div></div><div><h3>Results</h3><div>A total of 267,925 participants with a mean baseline age of 57.0 years were included in the primary analysis. Of these, 409 (0.15 %) reported experiencing EVP. During a median (Q1, Q3) follow-up time of 13.6 years, 33,526 (12.5 %) participants developed mental disorders, and 976 (0.4 %) experienced suicide-related behavior. EVP was associated with a higher risk of any mental disorders (adjusted Hazard Ratio [AHR]: 1.889, 95 % CI: 1.480, 2.412), Schizophrenia (AHR: 4.659, 95 % CI: 1.717, 12.645), mood disorders (AHR: 1.748, 95 % CI: 1.275, 2.397), and stress-related disorders (AHR: 2.088, 95 % CI: 1.481, 2.943). Pregnancy loss, gestational diabetes, hemoglobin levels, and the neutrophil-to-lymphocyte ratio mediate these associations. Mood disorders was a core node linking mental disorders to suicide-related behaviors.</div></div><div><h3>Conclusions</h3><div>EVP is associated with an increased risk of various mental disorders. Long-term mental health surveillance in women experiencing EVP is important, while further exploration on the underlying mechanism is required.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"388 ","pages":"Article 119706"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term mental health disorders and suicidal behaviors linked to excessive vomiting during pregnancy: Evidence from the UK biobank\",\"authors\":\"Xiaona Na , Xijie Wang , Din Son Tan, Yufeng Tan, Celi Yang, Junhan Zhang, Yucheng Yang, John S. Ji, Ai Zhao\",\"doi\":\"10.1016/j.jad.2025.119706\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The long-term effect of excessive vomiting during pregnancy (EVP) on women's mental health remains unclear. We aimed to investigate the association of EVP with the risks of mental disorders and suicide-related behaviors, and the potential influence of adverse pregnancy outcomes (APOs).</div></div><div><h3>Method</h3><div>267,925 female participants without a prior history of mental disorders at baseline were recruited from the UK Biobank Study. Multivariable Cox proportional hazards models were used to estimate the associations between EVP and the risk of mental disorders and suicide-related behaviors. Mediation and network analyses were conducted to assess the role of other APOs.</div></div><div><h3>Results</h3><div>A total of 267,925 participants with a mean baseline age of 57.0 years were included in the primary analysis. Of these, 409 (0.15 %) reported experiencing EVP. During a median (Q1, Q3) follow-up time of 13.6 years, 33,526 (12.5 %) participants developed mental disorders, and 976 (0.4 %) experienced suicide-related behavior. EVP was associated with a higher risk of any mental disorders (adjusted Hazard Ratio [AHR]: 1.889, 95 % CI: 1.480, 2.412), Schizophrenia (AHR: 4.659, 95 % CI: 1.717, 12.645), mood disorders (AHR: 1.748, 95 % CI: 1.275, 2.397), and stress-related disorders (AHR: 2.088, 95 % CI: 1.481, 2.943). Pregnancy loss, gestational diabetes, hemoglobin levels, and the neutrophil-to-lymphocyte ratio mediate these associations. Mood disorders was a core node linking mental disorders to suicide-related behaviors.</div></div><div><h3>Conclusions</h3><div>EVP is associated with an increased risk of various mental disorders. Long-term mental health surveillance in women experiencing EVP is important, while further exploration on the underlying mechanism is required.</div></div>\",\"PeriodicalId\":14963,\"journal\":{\"name\":\"Journal of affective disorders\",\"volume\":\"388 \",\"pages\":\"Article 119706\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of affective disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165032725011486\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725011486","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Long-term mental health disorders and suicidal behaviors linked to excessive vomiting during pregnancy: Evidence from the UK biobank
Background
The long-term effect of excessive vomiting during pregnancy (EVP) on women's mental health remains unclear. We aimed to investigate the association of EVP with the risks of mental disorders and suicide-related behaviors, and the potential influence of adverse pregnancy outcomes (APOs).
Method
267,925 female participants without a prior history of mental disorders at baseline were recruited from the UK Biobank Study. Multivariable Cox proportional hazards models were used to estimate the associations between EVP and the risk of mental disorders and suicide-related behaviors. Mediation and network analyses were conducted to assess the role of other APOs.
Results
A total of 267,925 participants with a mean baseline age of 57.0 years were included in the primary analysis. Of these, 409 (0.15 %) reported experiencing EVP. During a median (Q1, Q3) follow-up time of 13.6 years, 33,526 (12.5 %) participants developed mental disorders, and 976 (0.4 %) experienced suicide-related behavior. EVP was associated with a higher risk of any mental disorders (adjusted Hazard Ratio [AHR]: 1.889, 95 % CI: 1.480, 2.412), Schizophrenia (AHR: 4.659, 95 % CI: 1.717, 12.645), mood disorders (AHR: 1.748, 95 % CI: 1.275, 2.397), and stress-related disorders (AHR: 2.088, 95 % CI: 1.481, 2.943). Pregnancy loss, gestational diabetes, hemoglobin levels, and the neutrophil-to-lymphocyte ratio mediate these associations. Mood disorders was a core node linking mental disorders to suicide-related behaviors.
Conclusions
EVP is associated with an increased risk of various mental disorders. Long-term mental health surveillance in women experiencing EVP is important, while further exploration on the underlying mechanism is required.
期刊介绍:
The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.