牙龈卟啉单胞菌荚膜K1血清型IgG血清阳性与妊娠早期中度至重度抑郁症状相关

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-06-18 DOI:10.1016/j.jad.2025.119710

Teodor T. Postolache , Qiong Sha , Eric Achtyes , Abhishek Wadhawan , Aline Dagdag , Niel T. Constantine , Lisa A. Brenner , Maureen E. Groer , Yvonne M. Edgerly , Janna Volkov , Kuei-Ling Hsu , Joshua Joseph , Andrew J. Hoisington , Vivek Thumbigere-Math , Robert E. Schifferle , Christopher A. Lowry , Robert K. Ernst , Richard Leach , Lena Brundin , Mark A. Reynolds

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引用次数: 0

摘要

背景：牙周病（PD）是一种常见的口腔感染，常在妊娠期加重。牙龈卟啉单胞菌（P. gingivalis）是PD的主要病原体，可促进全身炎症，动物抑郁样行为，并可转移到大脑和生殖道。其荚膜抗原（K1-K7）是关键的毒力因子。我们假设特异性牙龈假单胞菌荚膜K血清型阳性与妊娠期抑郁症状和全身性炎症有关。方法：在一组孕妇（N = 114）的前瞻性队列中，使用爱丁堡产后抑郁评定量表（EPDS，≥13表示中度至重度抑郁症状）在妊娠的每个三个月评估抑郁症状。检测血浆抗牙龈假单胞菌K1-K7血清型IgG抗体和促炎因子。统计分析包括Firth减少偏倚的逻辑回归和混合效应线性模型。结果：大约25% %的参与者至少有一种K血清型呈血清阳性。血清中牙龈假单胞菌K1血清型IgG阳性与妊娠早期中重度抑郁症状显著相关(EPDS≥13； = 0.035页)。此外，聚集K血清阳性与妊娠早期血浆IL-10水平升高显著相关（P ）局限性：我们没有评估PD的临床或放射表现、非荚膜牙龈卟啉卟啉抗原抗体或其他PD病原体的存在。结论：这些结果表明，在研究牙周病与妊娠期情感性失调之间的关系时，将IgG K血清阳性（除了局部口腔病原体外，还可能反映其远端易位）与临床、细菌学和放射学措施结合起来是很重要的。

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Porphyromonas gingivalis capsular K1 serotype IgG seropositivity is associated with moderate-to-severe depressive symptoms during the first trimester of pregnancy

Background

Periodontal disease (PD) is a common oral infection that is often exacerbated during pregnancy. Porphyromonas gingivalis (P. gingivalis), a keystone PD pathogen, promotes systemic inflammation, depressive-like behavior in animals, and can translocate to the brain and genital tract. Its capsular antigens (K1-K7) are key virulence factors. We hypothesized that seropositivity to specific P. gingivalis capsular K serotypes is associated with depressive symptoms and systemic inflammation during pregnancy.

Methods

In a prospective cohort of pregnant women (N = 114), depressive symptoms were assessed in each trimester of pregnancy using the Edinburgh Postnatal Depression Rating Scale (EPDS, ≥13 denoting moderate-to-severe depression symptoms). Plasma IgG antibodies against P. gingivalis K1-K7 serotypes and proinflammatory cytokines were measured. Statistical analyses included Firth's bias-reduced logistic regression and mixed-effects linear models.

Results

Approximately 25 % of participants were seropositive for at least one K serotype. IgG seropositivity to P. gingivalis K1 serotype was significantly associated with moderate-to-severe depressive symptoms during the first trimester (EPDS≥13; P = 0.035). Additionally, aggregated K seropositivity was significantly associated with elevated plasma IL-10 levels during the first trimester (P < 0.05, adjusted for multiple comparisons). Other cytokines were unrelated to P. gingivalis K seropositivity.

Limitations

We did not assess clinical or radiological manifestations of PD, antibodies to non-capsular P. gingivalis antigens, or the presence of other PD pathogens.

Conclusion

These results suggest the importance of integrating IgG K seropositivity (which, in addition to local oral pathogens, may also reflect their distal translocation) with clinical, bacteriological and radiological measures when studying associations between PD and affective dysregulation in pregnancy.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.