肿瘤坏死因子- α和肿瘤坏死因子基因多态性对结核病发病率的影响研究。

IF 1.5 Q4 INFECTIOUS DISEASES
International Journal of Mycobacteriology Pub Date : 2025-04-01 Epub Date: 2025-06-20 DOI:10.4103/ijmy.ijmy_71_25
Jalaledin Ghanavi, Poopak Farnia
{"title":"肿瘤坏死因子- α和肿瘤坏死因子基因多态性对结核病发病率的影响研究。","authors":"Jalaledin Ghanavi, Poopak Farnia","doi":"10.4103/ijmy.ijmy_71_25","DOIUrl":null,"url":null,"abstract":"<p><p>Tuberculosis and its pathogen, Mycobacterium tuberculosis complex, are a major health challenge. The causative agent of tuberculosis is M. tuberculosis complex and is transmitted through airborne droplets. Tumor necrosis factor-alpha (TNF-α) is one of the cytokines that mediate a major role in the cellular immune response to tuberculosis and is essential for pathogen clearance, control of mycobacterial growth, and facilitation of apoptosis of infected cells. Susceptibility to tuberculosis and disease progression are influenced by environmental factors and the host's genetic predisposition. TNF polymorphisms affect disease susceptibility and patient response to drugs and treatment. Various studies have been conducted to associate TNF polymorphisms with susceptibility to tuberculosis. This activity aims to review the role of TNF-α cytokine and the impact of its polymorphisms on the occurrence of tuberculosis and compiles recent mechanistic and epidemiological findings.</p>","PeriodicalId":14133,"journal":{"name":"International Journal of Mycobacteriology","volume":"14 2","pages":"89-95"},"PeriodicalIF":1.5000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis.\",\"authors\":\"Jalaledin Ghanavi, Poopak Farnia\",\"doi\":\"10.4103/ijmy.ijmy_71_25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tuberculosis and its pathogen, Mycobacterium tuberculosis complex, are a major health challenge. The causative agent of tuberculosis is M. tuberculosis complex and is transmitted through airborne droplets. Tumor necrosis factor-alpha (TNF-α) is one of the cytokines that mediate a major role in the cellular immune response to tuberculosis and is essential for pathogen clearance, control of mycobacterial growth, and facilitation of apoptosis of infected cells. Susceptibility to tuberculosis and disease progression are influenced by environmental factors and the host's genetic predisposition. TNF polymorphisms affect disease susceptibility and patient response to drugs and treatment. Various studies have been conducted to associate TNF polymorphisms with susceptibility to tuberculosis. This activity aims to review the role of TNF-α cytokine and the impact of its polymorphisms on the occurrence of tuberculosis and compiles recent mechanistic and epidemiological findings.</p>\",\"PeriodicalId\":14133,\"journal\":{\"name\":\"International Journal of Mycobacteriology\",\"volume\":\"14 2\",\"pages\":\"89-95\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Mycobacteriology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijmy.ijmy_71_25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Mycobacteriology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijmy.ijmy_71_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/20 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

结核病及其病原体结核分枝杆菌复合体是一项重大的健康挑战。结核病的病原体是结核分枝杆菌复合体,并通过空气飞沫传播。肿瘤坏死因子-α (TNF-α)是介导结核细胞免疫应答的主要细胞因子之一,对病原体清除、控制分枝杆菌生长和促进感染细胞凋亡至关重要。结核病的易感性和疾病进展受环境因素和宿主遗传易感性的影响。TNF多态性影响疾病易感性和患者对药物和治疗的反应。已经进行了各种研究,将TNF多态性与结核病易感性联系起来。该活动旨在回顾TNF-α细胞因子的作用及其多态性对结核病发生的影响,并汇编最近的机制和流行病学发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis.

Tuberculosis and its pathogen, Mycobacterium tuberculosis complex, are a major health challenge. The causative agent of tuberculosis is M. tuberculosis complex and is transmitted through airborne droplets. Tumor necrosis factor-alpha (TNF-α) is one of the cytokines that mediate a major role in the cellular immune response to tuberculosis and is essential for pathogen clearance, control of mycobacterial growth, and facilitation of apoptosis of infected cells. Susceptibility to tuberculosis and disease progression are influenced by environmental factors and the host's genetic predisposition. TNF polymorphisms affect disease susceptibility and patient response to drugs and treatment. Various studies have been conducted to associate TNF polymorphisms with susceptibility to tuberculosis. This activity aims to review the role of TNF-α cytokine and the impact of its polymorphisms on the occurrence of tuberculosis and compiles recent mechanistic and epidemiological findings.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
2.20
自引率
25.00%
发文量
62
审稿时长
7 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信