Juan Wang, Anders Blomberg, Magnus Ekström, Hans Lennart Persson, Magnus Sköld, Kjell Torén, Xingwu Zhou, Andrei Malinovschi, Christer Janson
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Data on current physician-diagnosed asthma, respiratory symptoms and comorbidities were obtained via a questionnaire.</p><p><strong>Results: </strong>The prevalence of current asthma was 6.3%. Current asthma was independently associated with a higher prevalence of hypertension (OR=1.30; 95% CI 1.16 to 1.46), hyperlipidaemia (OR=1.20; 95% CI 1.04 to 1.39), diabetes (OR=1.42; 95% CI 1.16 to 1.75), coeliac disease (OR=2.52; 95% CI 1.61 to 3.95) and rheumatic disease (OR=1.43; 95% CI 1.16 to 1.78). Asthma was also associated with higher levels of CRP (beta=0.25; 95% CI 0.06 to 0.44) and HbA1c (beta=0.47; 95% CI 0.18 to 0.77). In those with asthma, lower FVC % predicted was associated with a higher likelihood of hypertension (OR=1.10; 95% CI 1.01 to 1.19), diabetes (OR=1.47; 95% CI 1.26 to 1.71) and rheumatic disease (OR=1.22; 95% CI 1.05 to 1.42). Lower FEV<sub>1</sub> % predicted was associated with a higher likelihood of diabetes (OR=1.27; 95% CI 1.12 to 1.44). FVC % and FEV<sub>1</sub> % predicted were negatively associated with CRP and HbA1c.</p><p><strong>Conclusions: </strong>Our findings suggest that in middle-aged people, asthma is independently associated with common comorbidities such as hypertension, diabetes and rheumatic disease, as well as elevated CRP and blood glucose. 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This study aimed to compare comorbidities and systemic inflammation between those with and without current asthma and to identify characteristics linked to comorbidities and biomarkers.</p><p><strong>Methods: </strong>In a cross-sectional analysis of 28 828 people aged 50-64 in the Swedish CArdioPulmonary bioImage Study, assessments included postbronchodilator forced expiratory volume in 1 s (FEV<sub>1</sub>), forced vital capacity (FVC), serum levels of C reactive protein (CRP) and haemoglobin A1c (HbA1c). Data on current physician-diagnosed asthma, respiratory symptoms and comorbidities were obtained via a questionnaire.</p><p><strong>Results: </strong>The prevalence of current asthma was 6.3%. 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引用次数: 0
摘要
简介：哮喘可能增加合并症和全身性炎症的风险，但缺乏人群数据。本研究旨在比较哮喘患者和非哮喘患者的合并症和全身性炎症，并确定与合并症和生物标志物相关的特征。方法：在瑞典心肺生物图像研究中对28828名年龄在50-64岁之间的患者进行横断面分析，评估包括支气管扩张剂后1秒用力呼气量（FEV1）、用力肺活量（FVC）、血清C反应蛋白（CRP）和血红蛋白A1c （HbA1c）水平。通过问卷调查获得当前医生诊断的哮喘、呼吸道症状和合并症的数据。结果：哮喘患病率为6.3%。当前哮喘与较高的高血压患病率独立相关(OR=1.30；95% CI 1.16 ~ 1.46)，高脂血症(OR=1.20；95% CI 1.04 - 1.39)，糖尿病(OR=1.42；95% CI 1.16 - 1.75)，乳糜泻(OR=2.52；95% CI 1.61 - 3.95)和风湿病(OR=1.43；95% CI 1.16 - 1.78)。哮喘也与CRP水平升高有关(β =0.25；95% CI 0.06 ~ 0.44)和HbA1c (β =0.47；95% CI 0.18 ~ 0.77)。在哮喘患者中，较低的FVC %预测与较高的高血压可能性相关(OR=1.10；95% CI 1.01 ~ 1.19)，糖尿病(OR=1.47；95% CI 1.26 - 1.71)和风湿病(OR=1.22；95% CI 1.05 ~ 1.42)。较低的FEV1 %预测与较高的糖尿病可能性相关(OR=1.27；95% CI 1.12 - 1.44)。预测FVC %和fev1%与CRP和HbA1c呈负相关。结论：我们的研究结果表明，在中年人中，哮喘与高血压、糖尿病和风湿病等常见合并症以及CRP和血糖升高独立相关。我们的数据表明，某些关联与哮喘患者的肺功能损害有关。
Asthma and extrapulmonary comorbidities in a middle-aged general population: results from the SCAPIS study.
Introduction: Asthma may increase the risk of comorbidities and systemic inflammation, but population data are scarce. This study aimed to compare comorbidities and systemic inflammation between those with and without current asthma and to identify characteristics linked to comorbidities and biomarkers.
Methods: In a cross-sectional analysis of 28 828 people aged 50-64 in the Swedish CArdioPulmonary bioImage Study, assessments included postbronchodilator forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), serum levels of C reactive protein (CRP) and haemoglobin A1c (HbA1c). Data on current physician-diagnosed asthma, respiratory symptoms and comorbidities were obtained via a questionnaire.
Results: The prevalence of current asthma was 6.3%. Current asthma was independently associated with a higher prevalence of hypertension (OR=1.30; 95% CI 1.16 to 1.46), hyperlipidaemia (OR=1.20; 95% CI 1.04 to 1.39), diabetes (OR=1.42; 95% CI 1.16 to 1.75), coeliac disease (OR=2.52; 95% CI 1.61 to 3.95) and rheumatic disease (OR=1.43; 95% CI 1.16 to 1.78). Asthma was also associated with higher levels of CRP (beta=0.25; 95% CI 0.06 to 0.44) and HbA1c (beta=0.47; 95% CI 0.18 to 0.77). In those with asthma, lower FVC % predicted was associated with a higher likelihood of hypertension (OR=1.10; 95% CI 1.01 to 1.19), diabetes (OR=1.47; 95% CI 1.26 to 1.71) and rheumatic disease (OR=1.22; 95% CI 1.05 to 1.42). Lower FEV1 % predicted was associated with a higher likelihood of diabetes (OR=1.27; 95% CI 1.12 to 1.44). FVC % and FEV1 % predicted were negatively associated with CRP and HbA1c.
Conclusions: Our findings suggest that in middle-aged people, asthma is independently associated with common comorbidities such as hypertension, diabetes and rheumatic disease, as well as elevated CRP and blood glucose. Our data suggest that some associations are connected with lung function impairment in those with asthma.
期刊介绍：
BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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