我妈妈呢?断奶后雌雄小鼠在多室社会行为任务中的适应性母性偏好

IF 3.5 Q2 IMMUNOLOGY
Maggie M. Slamin , Indra R. Bishnoi , Izabella M. Bankowski, Haley A. Norris, Evan A. Bordt
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引用次数: 0

摘要

对许多哺乳动物来说,最早也是最重要的社会纽带之一就是与母亲形成的纽带。母亲通常为后代的发育和生存提供必要的好处。越来越多的证据表明,即使动物获得独立,比如在断奶后的幼年时期,这种社会纽带也会保留下来。在这里,我们研究了幼年小鼠(出生后[P]26日)在断奶后是否保留识别和偏好母亲的能力。我们使用急性免疫激活剂进一步研究了这种结合的强度。在P26,雄性和雌性C57BL/6J小鼠腹腔注射内毒素脂多糖(LPS)或生理盐水对照(0.5 mg/kg)。四小时后,小鼠接受一个五室社会偏好任务(AGORA),其中包括它们的生母、一只性别和年龄匹配的新小鼠、一只性别和年龄匹配的兄弟姐妹、一个新物体和一个空房间。我们的研究结果表明,幼鼠表现出强烈的母性偏好,明显高于偶然性,高于任何其他社会或非社会刺激。虽然LPS暴露减少了调查所有刺激的时间,但幼崽母亲的偏好并未因LPS暴露而显著改变。这些影响在女性中尤为明显,而在P26阶段,男性开始出现向新探索方向的微妙转变。本研究中采用的新颖的多室任务提供了对社会关系如何演变和性别差异的更细致的理解。目前的研究结果表明,幼鼠对它们的母亲有强烈的社会偏好,这是对早期免疫激活的弹性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Where's my mom? Resilient maternal preference in post-weaning male and female mice within a multi-chamber social behavior task
One of the earliest and most important social bonds for many mammals is the bond formed with their mother. Mothers often provide essential benefits for offspring development and survival. Growing evidence suggests that this social bond is retained even when animals gain independence, such as during the juvenile period immediately following weaning. Here, we investigated whether or not juvenile mice (postnatal day [P]26) retain the ability to recognize and prefer their mothers post-weaning. We further investigated the strength of this bond using an acute immune activator. On P26, male and female C57BL/6J mice were intraperitoneally injected with the endotoxin lipopolysaccharide (LPS) or saline control (0.5 mg/kg). Four hours later, mice were subject to a five-chamber social preference task (the AGORA) containing their biological mother, a sex- and age-matched novel mouse, a sex- and age-matched sibling, a novel object, and an empty chamber. Our findings reveal that juvenile mice exhibit a strong maternal preference, which was significantly greater than chance and higher compared to any other social or non-social stimuli. While LPS exposure reduced the time spent investigating all stimuli, juvenile maternal preference was not significantly altered by LPS exposure. These effects were especially pronounced in females, while subtle shifts towards novel exploration began to emerge in males by P26. The novel multi-chamber task employed in the present study offered a more nuanced understanding of how social bonds evolve and vary across sex. The current findings suggest that juvenile mice have a robust social preference for their mother that is resilient to early-life immune activation.
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
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0
审稿时长
97 days
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