一项为期2年的队列研究:探索潜伏性梅毒的个性化治疗策略。

IF 1.8 4区 医学 Q3 INFECTIOUS DISEASES
Sexual health Pub Date : 2025-06-01 DOI:10.1071/SH25047
Jia-Wen Xie, Ya-Wen Zheng, Shu-Hao Fan, Yin-Feng Guo, Ying Zheng, Yu Lin, Man-Li Tong, Li-Rong Lin
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引用次数: 0

摘要

单纯依赖潜伏期梅毒可能导致过度的治疗策略。利用非螺旋体免疫球蛋白M (IgM)抗体来评估梅毒活动和定制治疗策略可能提供增强的治疗优势。目的探讨非螺旋体IgM抗体是否可作为评估潜伏性梅毒活动性的血清学指标,为个性化治疗策略提供依据。方法对412例潜伏性梅毒患者进行非密螺旋体IgM抗体检测,随访2年,分析其血清转化率(由血清阳性转为血清阴性),评价非密螺旋体IgM抗体是否能评估潜伏性梅毒的活动性。结果非螺旋体IgM阳性组血清转化率较阴性组低(P =0.0178),血清转化率较阴性组慢(风险比:0.386)。早期患者非密螺旋体IgM抗体水平高于晚期患者(P =0.018)。老年患者非密螺旋体IgM抗体水平低于非老年患者(P =0.0022)。结论非螺旋体IgM阳性的潜伏性梅毒患者血清转化时间较长,血清逆转率较低,梅毒活动性较高。非密螺旋体IgM抗体可作为检测潜伏梅毒患者梅毒活动的血清学标志物。建议在治疗前检测非螺旋体IgM抗体,以确定梅毒活动,以便进行个性化治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring syphilis activity for personalized treatment strategies in latent syphilis: a 2-year cohort study.

Background Relying simply on the stage of latent syphilis may lead to excessive treatment strategies. Utilizing nontreponemal immunoglobulin M (IgM) antibodies to assess syphilis activity and tailor treatment strategies may offer enhanced therapeutic advantages. Objectives To investigate whether nontreponemal IgM antibodies can serve as a serological marker for assessing the activity of latent syphilis and inform personalized treatment strategies. Methods We evaluated nontreponemal IgM antibodies in 412 latent syphilis patients and conducted a 2-year follow up to analyze their rate of seroconversion (the change from seropositive to seronegative status), to evaluate whether nontreponemal IgM antibodies could assess the activity of latent syphilis. Results The positive nontreponemal IgM group demonstrated a lower seroconversion rate (P =0.0178) and achieved seroconversion slower compared with the negative group (hazard ratio: 0.386). Early-stage patients exhibited higher nontreponemal IgM antibody levels (P P =0.018) than late-stage patients. Elderly patients showed lower nontreponemal IgM antibody levels (P P =0.0022) than non-elderly patients. Conclusions Latent syphilis patients with positive nontreponemal IgM require a longer time to seroconversion and exhibit a lower seroreversion rate, indicating their higher syphilis activity. Nontreponemal IgM antibodies can serve as a serological marker for detecting syphilis activity in latent syphilis. It is recommended to test for nontreponemal IgM antibodies before treatment to identify syphilis activity for personalized treatment.

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来源期刊
Sexual health
Sexual health 医学-传染病学
CiteScore
2.30
自引率
12.50%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Sexual Health publishes original and significant contributions to the fields of sexual health including HIV/AIDS, Sexually transmissible infections, issues of sexuality and relevant areas of reproductive health. This journal is directed towards those working in sexual health as clinicians, public health practitioners, researchers in behavioural, clinical, laboratory, public health or social, sciences. The journal publishes peer reviewed original research, editorials, review articles, topical debates, case reports and critical correspondence. Officially sponsored by: The Australasian Chapter of Sexual Health Medicine of RACP Sexual Health Society of Queensland Sexual Health is the official journal of the International Union against Sexually Transmitted Infections (IUSTI), Asia-Pacific, and the Asia-Oceania Federation of Sexology.
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