{"title":"一项为期2年的队列研究:探索潜伏性梅毒的个性化治疗策略。","authors":"Jia-Wen Xie, Ya-Wen Zheng, Shu-Hao Fan, Yin-Feng Guo, Ying Zheng, Yu Lin, Man-Li Tong, Li-Rong Lin","doi":"10.1071/SH25047","DOIUrl":null,"url":null,"abstract":"<p><p>Background Relying simply on the stage of latent syphilis may lead to excessive treatment strategies. Utilizing nontreponemal immunoglobulin M (IgM) antibodies to assess syphilis activity and tailor treatment strategies may offer enhanced therapeutic advantages. Objectives To investigate whether nontreponemal IgM antibodies can serve as a serological marker for assessing the activity of latent syphilis and inform personalized treatment strategies. Methods We evaluated nontreponemal IgM antibodies in 412 latent syphilis patients and conducted a 2-year follow up to analyze their rate of seroconversion (the change from seropositive to seronegative status), to evaluate whether nontreponemal IgM antibodies could assess the activity of latent syphilis. Results The positive nontreponemal IgM group demonstrated a lower seroconversion rate (P =0.0178) and achieved seroconversion slower compared with the negative group (hazard ratio: 0.386). Early-stage patients exhibited higher nontreponemal IgM antibody levels (P P =0.018) than late-stage patients. Elderly patients showed lower nontreponemal IgM antibody levels (P P =0.0022) than non-elderly patients. Conclusions Latent syphilis patients with positive nontreponemal IgM require a longer time to seroconversion and exhibit a lower seroreversion rate, indicating their higher syphilis activity. Nontreponemal IgM antibodies can serve as a serological marker for detecting syphilis activity in latent syphilis. It is recommended to test for nontreponemal IgM antibodies before treatment to identify syphilis activity for personalized treatment.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring syphilis activity for personalized treatment strategies in latent syphilis: a 2-year cohort study.\",\"authors\":\"Jia-Wen Xie, Ya-Wen Zheng, Shu-Hao Fan, Yin-Feng Guo, Ying Zheng, Yu Lin, Man-Li Tong, Li-Rong Lin\",\"doi\":\"10.1071/SH25047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Background Relying simply on the stage of latent syphilis may lead to excessive treatment strategies. Utilizing nontreponemal immunoglobulin M (IgM) antibodies to assess syphilis activity and tailor treatment strategies may offer enhanced therapeutic advantages. Objectives To investigate whether nontreponemal IgM antibodies can serve as a serological marker for assessing the activity of latent syphilis and inform personalized treatment strategies. Methods We evaluated nontreponemal IgM antibodies in 412 latent syphilis patients and conducted a 2-year follow up to analyze their rate of seroconversion (the change from seropositive to seronegative status), to evaluate whether nontreponemal IgM antibodies could assess the activity of latent syphilis. Results The positive nontreponemal IgM group demonstrated a lower seroconversion rate (P =0.0178) and achieved seroconversion slower compared with the negative group (hazard ratio: 0.386). Early-stage patients exhibited higher nontreponemal IgM antibody levels (P P =0.018) than late-stage patients. Elderly patients showed lower nontreponemal IgM antibody levels (P P =0.0022) than non-elderly patients. Conclusions Latent syphilis patients with positive nontreponemal IgM require a longer time to seroconversion and exhibit a lower seroreversion rate, indicating their higher syphilis activity. Nontreponemal IgM antibodies can serve as a serological marker for detecting syphilis activity in latent syphilis. It is recommended to test for nontreponemal IgM antibodies before treatment to identify syphilis activity for personalized treatment.</p>\",\"PeriodicalId\":22165,\"journal\":{\"name\":\"Sexual health\",\"volume\":\"22 \",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sexual health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1071/SH25047\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sexual health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1071/SH25047","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Exploring syphilis activity for personalized treatment strategies in latent syphilis: a 2-year cohort study.
Background Relying simply on the stage of latent syphilis may lead to excessive treatment strategies. Utilizing nontreponemal immunoglobulin M (IgM) antibodies to assess syphilis activity and tailor treatment strategies may offer enhanced therapeutic advantages. Objectives To investigate whether nontreponemal IgM antibodies can serve as a serological marker for assessing the activity of latent syphilis and inform personalized treatment strategies. Methods We evaluated nontreponemal IgM antibodies in 412 latent syphilis patients and conducted a 2-year follow up to analyze their rate of seroconversion (the change from seropositive to seronegative status), to evaluate whether nontreponemal IgM antibodies could assess the activity of latent syphilis. Results The positive nontreponemal IgM group demonstrated a lower seroconversion rate (P =0.0178) and achieved seroconversion slower compared with the negative group (hazard ratio: 0.386). Early-stage patients exhibited higher nontreponemal IgM antibody levels (P P =0.018) than late-stage patients. Elderly patients showed lower nontreponemal IgM antibody levels (P P =0.0022) than non-elderly patients. Conclusions Latent syphilis patients with positive nontreponemal IgM require a longer time to seroconversion and exhibit a lower seroreversion rate, indicating their higher syphilis activity. Nontreponemal IgM antibodies can serve as a serological marker for detecting syphilis activity in latent syphilis. It is recommended to test for nontreponemal IgM antibodies before treatment to identify syphilis activity for personalized treatment.
期刊介绍:
Sexual Health publishes original and significant contributions to the fields of sexual health including HIV/AIDS, Sexually transmissible infections, issues of sexuality and relevant areas of reproductive health. This journal is directed towards those working in sexual health as clinicians, public health practitioners, researchers in behavioural, clinical, laboratory, public health or social, sciences. The journal publishes peer reviewed original research, editorials, review articles, topical debates, case reports and critical correspondence.
Officially sponsored by:
The Australasian Chapter of Sexual Health Medicine of RACP
Sexual Health Society of Queensland
Sexual Health is the official journal of the International Union against Sexually Transmitted Infections (IUSTI), Asia-Pacific, and the Asia-Oceania Federation of Sexology.