{"title":"基于磷脂复合物技术的Esculin递送系统：溶解度优化及抗菌活性提高研究。","authors":"Jiale Mao, Lixin Yi, Honghui Zhao, Jiapei Wu, Xu Zhao","doi":"10.1080/14786419.2025.2521388","DOIUrl":null,"url":null,"abstract":"<p><p>Esculin (ES) has antibacterial effects, but its low solubility and bioavailability limit applications. This study prepared an esculin phospholipid complex (ES-PC) <i>via</i> solvent evaporation. SEM, FTIR, XRD and <sup>1</sup>H-NMR verified its amorphous structure formed by intermolecular forces. The solubility in water and n-octanol increased by 13.8-and 7.3-fold respectively compared to ES, and its hydrophilicity improved as the octanol-water partition coefficient decreased. <i>In vitro</i>, ES-PC had a cumulative dissolution rate of over 85% within 4 h, much higher than ES. When used in a composite film for pork preservation, ES-PC inhibited bacterial growth, maintained low pH and TVB-N values, and extended the meat's shelf-life. This research provides a new way to develop delivery systems for insoluble drugs, expanding their applications.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Esculin delivery system based on phospholipid complex technology: research on solubility optimization and antibacterial activity improvement.\",\"authors\":\"Jiale Mao, Lixin Yi, Honghui Zhao, Jiapei Wu, Xu Zhao\",\"doi\":\"10.1080/14786419.2025.2521388\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Esculin (ES) has antibacterial effects, but its low solubility and bioavailability limit applications. This study prepared an esculin phospholipid complex (ES-PC) <i>via</i> solvent evaporation. SEM, FTIR, XRD and <sup>1</sup>H-NMR verified its amorphous structure formed by intermolecular forces. The solubility in water and n-octanol increased by 13.8-and 7.3-fold respectively compared to ES, and its hydrophilicity improved as the octanol-water partition coefficient decreased. <i>In vitro</i>, ES-PC had a cumulative dissolution rate of over 85% within 4 h, much higher than ES. When used in a composite film for pork preservation, ES-PC inhibited bacterial growth, maintained low pH and TVB-N values, and extended the meat's shelf-life. This research provides a new way to develop delivery systems for insoluble drugs, expanding their applications.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2025.2521388\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2521388","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Esculin delivery system based on phospholipid complex technology: research on solubility optimization and antibacterial activity improvement.
Esculin (ES) has antibacterial effects, but its low solubility and bioavailability limit applications. This study prepared an esculin phospholipid complex (ES-PC) via solvent evaporation. SEM, FTIR, XRD and 1H-NMR verified its amorphous structure formed by intermolecular forces. The solubility in water and n-octanol increased by 13.8-and 7.3-fold respectively compared to ES, and its hydrophilicity improved as the octanol-water partition coefficient decreased. In vitro, ES-PC had a cumulative dissolution rate of over 85% within 4 h, much higher than ES. When used in a composite film for pork preservation, ES-PC inhibited bacterial growth, maintained low pH and TVB-N values, and extended the meat's shelf-life. This research provides a new way to develop delivery systems for insoluble drugs, expanding their applications.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
