皮质-皮质下网络中的GABA和Glx水平预测儿茶酚胺能对反应抑制的影响。

IF 5.5 3区 医学 Q1 CLINICAL NEUROLOGY
Journal of Psychopharmacology Pub Date : 2025-08-01 Epub Date: 2025-06-20 DOI:10.1177/02698811251340893
Anna Helin Koyun, Annett Werner, Paul Kuntke, Veit Roessner, Christian Beste, Ann-Kathrin Stock
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引用次数: 0

摘要

背景:皮质-皮质下网络在认知控制中起着重要作用。在这些神经回路中,神经递质如γ -氨基丁酸(GABA)、谷氨酸和儿茶酚胺对反应控制和(运动)反应抑制起着至关重要的调节作用。尽管这些递质系统之间存在明显的相互关系,但基线GABA和谷氨酸-谷氨酰胺(Glx)水平在预测/影响儿茶酚胺能作用中的作用仍不清楚。目的:为了解决这一知识差距,我们研究了儿茶酚胺的行为影响有多少(以及哪些方面)是由控制相关皮层网络中的gaba能和谷氨酸能水平引起的。方法:利用质子磁共振波谱技术,我们评估了纹状体、前扣带皮层和辅助运动皮层(SMA)的基线GABA+和Glx水平,以及它们对儿茶酚胺能调节反应选择和抑制性能的预测价值。为此,我们对健康成人给予低剂量和高剂量的哌醋甲酯(MPH),并检查基线GABA+和Glx是否与剂量依赖性MPH对反应控制的影响有关。结果/结果:我们首次在健康成人样本中证明,认知控制相关皮质区域的GABA+/Glx水平表明mph诱导的反应抑制效应的程度。具体来说,纹状体GABA+/Glx水平预测了低MPH剂量下更好的反应抑制性能。相反,(预)SMA的GABA+/Glx水平与高MPH剂量引起的反应抑制性能损伤相关。结论/解释:GABA+/Glx水平与MPH剂量依赖性对认知控制过程的预测相关性为先前报道的异质性MPH效应背后的神经机制提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition.

GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition.

GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition.

GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition.

Background: Cortico-subcortical networks play a fundamental role in cognitive control. Within these circuits, neurotransmitters such as gamma-aminobutyric acid (GABA), glutamate, and catecholamines crucially modulate response control and (motor) response inhibition. Despite the evident interrelation between these transmitter systems, the role of baseline GABA and glutamate-glutamine (Glx) levels in predicting/influencing catecholaminergic effects has remained rather unclear.

Aims: Addressing this knowledge gap, we investigated the question how much (and which facets) of behavioral effects attributed to catecholamines are due to GABAergic and glutamatergic levels in control-relevant cortical networks.

Methods: Using proton-magnetic resonance spectroscopy, we assessed baseline GABA+ and Glx levels within the striatum, the anterior cingulate cortex, and the (pre-)supplementary motor cortex ((pre-)SMA), and their predictive value for catecholaminergic modulation of response selection and inhibition performance. For this purpose, we administered low and high doses of methylphenidate (MPH) to healthy adults and examined whether baseline GABA+ and Glx were associated with dose-dependent MPH effects on response control.

Results/outcomes: For the first time in a sample of healthy adults, we demonstrate that GABA+/Glx levels in cognitive control-relevant cortical areas are indicative of the magnitude of MPH-induced effects on response inhibition. Specifically, striatal GABA+/Glx levels predicted better response inhibition performance under the administration of low MPH doses. In contrast, (pre-)SMA GABA+/Glx levels were associated with high MPH dose-induced impairments of response inhibition performance.

Conclusion/interpretation: The predictive relevance of GABA+/Glx levels for MPH dose-dependent effects on cognitive control processes provides valuable insights into the neural mechanisms underlying the previously reported heterogeneous MPH effects.

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来源期刊
Journal of Psychopharmacology
Journal of Psychopharmacology 医学-精神病学
CiteScore
8.60
自引率
4.90%
发文量
126
审稿时长
3-8 weeks
期刊介绍: The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.
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