Rebecca Grønning, Anna Jeppsson, Per Hellström, Kerstin Andrén, Katarina Laurell, Dan Farahmand, Henrik Zetterberg, Kaj Blennow, Carsten Wikkelsø, Mats Tullberg
{"title":"特发性常压脑积水术后脑室脑脊液生物标志物变化与临床预后的相关性","authors":"Rebecca Grønning, Anna Jeppsson, Per Hellström, Kerstin Andrén, Katarina Laurell, Dan Farahmand, Henrik Zetterberg, Kaj Blennow, Carsten Wikkelsø, Mats Tullberg","doi":"10.1177/13872877251350308","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundVentricular cerebrospinal fluid (CSF) was analysed peri- and postoperatively to elucidate the pathophysiology of Idiopathic normal pressure hydrocephalus (iNPH).ObjectiveTo capture the dynamics of biomarkers and their relation to clinical symptoms.MethodsIn 113 consecutively diagnosed patients, the Hellström iNPH scale was used to quantify symptom burden pre- and postoperatively. CSF was collected at shunt insertion and postoperatively by shunt reservoir puncture, and analyzed for concentrations of GFAP, YKL40, MCP-1, NfL, Aβ<sub>40</sub>, sAβPPα, sAβPPβ, GAP43, Alzheimer's disease biomarkers Aβ<sub>42</sub>, Aβ<sub>42/40</sub>, total tau (T-tau), phosphorylated tau (P-tau), and neurogranin.ResultsConcentrations increased postoperatively for Aβ<sub>40</sub> (134%), Aβ<sub>42</sub> (106%), sAβPPα (112%), sAβPPβ (83%), NfL (128%), YKL40 (86%), GAP43 (124%), and MCP-1 (5%) (p < 0.001, MCP-1 (p = 0.03)), while mean concentration reductions were seen in T-tau (32%), GFAP (31%), neurogranin (49%), and Aβ<sub>42/40</sub> (10%) (p < 0.001). A higher perioperative concentration of AβPPβ correlated with less pronounced gait disturbance (R<sub>p</sub> 0.20 (0.01-0.38) (95% CI)), whereas higher levels of NfL (-0.23 (-0.41-(-)0.04) and MCP-1 (-0.21 (-0.37-(-)0.01)) correlated with impaired cognition. Higher MCP-1 correlated with a lower balance domain score (-0.20 (-0.37-(-)0.01)). Postoperative increases in levels of Aβ<sub>40</sub> (R<sub>s</sub> 0.27 (0.05-0.46)), Aβ<sub>42</sub> (R<sub>s</sub> 0.24 (0.02-0.44)) and YKL40 (R<sub>s</sub> 0.22 (-0.00-0.43)) correlated with gait improvement, and a postoperative increase in Aβ<sub>40</sub> (R<sub>s</sub> 0.36 (0.05-0.60)) was associated with improvement in urinary continence (p 0.01-0.05).ConclusionsCSF biomarker concentrations change after shunt insertion. These changes, seen as increased concentrations for some biomarkers and decreased concentrations for others, are associated with improvement in core clinical symptoms and may illustrate reversibility of pathophysiological mechanisms in iNPH.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251350308"},"PeriodicalIF":3.1000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284331/pdf/","citationCount":"0","resultStr":"{\"title\":\"Postoperative changes in ventricular cerebrospinal fluid biomarkers with correlation to clinical outcome in idiopathic normal pressure hydrocephalus.\",\"authors\":\"Rebecca Grønning, Anna Jeppsson, Per Hellström, Kerstin Andrén, Katarina Laurell, Dan Farahmand, Henrik Zetterberg, Kaj Blennow, Carsten Wikkelsø, Mats Tullberg\",\"doi\":\"10.1177/13872877251350308\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>BackgroundVentricular cerebrospinal fluid (CSF) was analysed peri- and postoperatively to elucidate the pathophysiology of Idiopathic normal pressure hydrocephalus (iNPH).ObjectiveTo capture the dynamics of biomarkers and their relation to clinical symptoms.MethodsIn 113 consecutively diagnosed patients, the Hellström iNPH scale was used to quantify symptom burden pre- and postoperatively. CSF was collected at shunt insertion and postoperatively by shunt reservoir puncture, and analyzed for concentrations of GFAP, YKL40, MCP-1, NfL, Aβ<sub>40</sub>, sAβPPα, sAβPPβ, GAP43, Alzheimer's disease biomarkers Aβ<sub>42</sub>, Aβ<sub>42/40</sub>, total tau (T-tau), phosphorylated tau (P-tau), and neurogranin.ResultsConcentrations increased postoperatively for Aβ<sub>40</sub> (134%), Aβ<sub>42</sub> (106%), sAβPPα (112%), sAβPPβ (83%), NfL (128%), YKL40 (86%), GAP43 (124%), and MCP-1 (5%) (p < 0.001, MCP-1 (p = 0.03)), while mean concentration reductions were seen in T-tau (32%), GFAP (31%), neurogranin (49%), and Aβ<sub>42/40</sub> (10%) (p < 0.001). A higher perioperative concentration of AβPPβ correlated with less pronounced gait disturbance (R<sub>p</sub> 0.20 (0.01-0.38) (95% CI)), whereas higher levels of NfL (-0.23 (-0.41-(-)0.04) and MCP-1 (-0.21 (-0.37-(-)0.01)) correlated with impaired cognition. Higher MCP-1 correlated with a lower balance domain score (-0.20 (-0.37-(-)0.01)). Postoperative increases in levels of Aβ<sub>40</sub> (R<sub>s</sub> 0.27 (0.05-0.46)), Aβ<sub>42</sub> (R<sub>s</sub> 0.24 (0.02-0.44)) and YKL40 (R<sub>s</sub> 0.22 (-0.00-0.43)) correlated with gait improvement, and a postoperative increase in Aβ<sub>40</sub> (R<sub>s</sub> 0.36 (0.05-0.60)) was associated with improvement in urinary continence (p 0.01-0.05).ConclusionsCSF biomarker concentrations change after shunt insertion. These changes, seen as increased concentrations for some biomarkers and decreased concentrations for others, are associated with improvement in core clinical symptoms and may illustrate reversibility of pathophysiological mechanisms in iNPH.</p>\",\"PeriodicalId\":14929,\"journal\":{\"name\":\"Journal of Alzheimer's Disease\",\"volume\":\" \",\"pages\":\"13872877251350308\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284331/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/13872877251350308\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13872877251350308","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Postoperative changes in ventricular cerebrospinal fluid biomarkers with correlation to clinical outcome in idiopathic normal pressure hydrocephalus.
BackgroundVentricular cerebrospinal fluid (CSF) was analysed peri- and postoperatively to elucidate the pathophysiology of Idiopathic normal pressure hydrocephalus (iNPH).ObjectiveTo capture the dynamics of biomarkers and their relation to clinical symptoms.MethodsIn 113 consecutively diagnosed patients, the Hellström iNPH scale was used to quantify symptom burden pre- and postoperatively. CSF was collected at shunt insertion and postoperatively by shunt reservoir puncture, and analyzed for concentrations of GFAP, YKL40, MCP-1, NfL, Aβ40, sAβPPα, sAβPPβ, GAP43, Alzheimer's disease biomarkers Aβ42, Aβ42/40, total tau (T-tau), phosphorylated tau (P-tau), and neurogranin.ResultsConcentrations increased postoperatively for Aβ40 (134%), Aβ42 (106%), sAβPPα (112%), sAβPPβ (83%), NfL (128%), YKL40 (86%), GAP43 (124%), and MCP-1 (5%) (p < 0.001, MCP-1 (p = 0.03)), while mean concentration reductions were seen in T-tau (32%), GFAP (31%), neurogranin (49%), and Aβ42/40 (10%) (p < 0.001). A higher perioperative concentration of AβPPβ correlated with less pronounced gait disturbance (Rp 0.20 (0.01-0.38) (95% CI)), whereas higher levels of NfL (-0.23 (-0.41-(-)0.04) and MCP-1 (-0.21 (-0.37-(-)0.01)) correlated with impaired cognition. Higher MCP-1 correlated with a lower balance domain score (-0.20 (-0.37-(-)0.01)). Postoperative increases in levels of Aβ40 (Rs 0.27 (0.05-0.46)), Aβ42 (Rs 0.24 (0.02-0.44)) and YKL40 (Rs 0.22 (-0.00-0.43)) correlated with gait improvement, and a postoperative increase in Aβ40 (Rs 0.36 (0.05-0.60)) was associated with improvement in urinary continence (p 0.01-0.05).ConclusionsCSF biomarker concentrations change after shunt insertion. These changes, seen as increased concentrations for some biomarkers and decreased concentrations for others, are associated with improvement in core clinical symptoms and may illustrate reversibility of pathophysiological mechanisms in iNPH.
期刊介绍：
The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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