Amol Mehta, Joshua Finesilver, Daryl Goldman, Tomoyoshi Shigematsu, Christopher P Kellner, Shahram Majidi, Reade De Leacy, Johanna Fifi, Michael Travis Caton
{"title":"目标利乐线圈治疗颅内小及甚小破裂动脉瘤的早期经验。","authors":"Amol Mehta, Joshua Finesilver, Daryl Goldman, Tomoyoshi Shigematsu, Christopher P Kellner, Shahram Majidi, Reade De Leacy, Johanna Fifi, Michael Travis Caton","doi":"10.1177/15910199251351735","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundEndovascular treatment of small (< 5 mm) and very small (≤ 3 mm) ruptured intracranial aneurysms remains technically challenging, historically carrying elevated procedural risks. Advances in coil technology, such as the Target Tetra Detachable Coil (TTDC), aim to improve embolization safety and efficacy. However, limited data exist on outcomes using TTDC coils specifically for ruptured aneurysms.ObjectiveTo evaluate the safety, angiographic efficacy, and clinical outcomes of TTDC for small and very small ruptured intracranial aneurysms.MethodsWe retrospectively analyzed 36 patients with ruptured intracranial aneurysms ≤5 mm treated using TTDC between 2023 and 2025 at a single center. Aneurysms were classified as small (<i>n</i> = 28) or very small (<i>n</i> = 8). Patient demographics, aneurysm characteristics, procedural details, angiographic outcomes, clinical outcomes, and complications were analyzed.ResultsMedian patient age was 57 years (IQR 43-73); 33.3% were male. The mean aneurysm dome height was 2.6 ± 0.9 mm, the mean neck diameter was 2.4 ± 0.7 mm, and the median dome-to-neck ratio was 1.0. Immediate complete occlusion (Raymond-Roy Class I) was achieved in 42.7% of aneurysms, and residual neck filling (Raymond-Roy Class II) in 25.0%. Follow-up imaging (mean 4.9 months) showed complete occlusion in 37.5% of aneurysms. Recanalization occurred in 29.2% of patients with repeat imaging and 6 (25%) requiring retreatment. Favorable clinical outcomes (mRS 0-2) occurred in 75.0%. Procedural complications occurred in 13.9% (five cases), including two intraprocedural perforations. No rebleeding occurred.ConclusionEarly experience with TTDC demonstrates safe, effective embolization for ruptured small and very small intracranial aneurysms, supporting the broader use of modern coils in these challenging lesions.</p>","PeriodicalId":14380,"journal":{"name":"Interventional Neuroradiology","volume":" ","pages":"15910199251351735"},"PeriodicalIF":1.7000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Early experience with Target Tetra coils for treatment of small and very small ruptured intracranial aneurysms.\",\"authors\":\"Amol Mehta, Joshua Finesilver, Daryl Goldman, Tomoyoshi Shigematsu, Christopher P Kellner, Shahram Majidi, Reade De Leacy, Johanna Fifi, Michael Travis Caton\",\"doi\":\"10.1177/15910199251351735\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>BackgroundEndovascular treatment of small (< 5 mm) and very small (≤ 3 mm) ruptured intracranial aneurysms remains technically challenging, historically carrying elevated procedural risks. Advances in coil technology, such as the Target Tetra Detachable Coil (TTDC), aim to improve embolization safety and efficacy. However, limited data exist on outcomes using TTDC coils specifically for ruptured aneurysms.ObjectiveTo evaluate the safety, angiographic efficacy, and clinical outcomes of TTDC for small and very small ruptured intracranial aneurysms.MethodsWe retrospectively analyzed 36 patients with ruptured intracranial aneurysms ≤5 mm treated using TTDC between 2023 and 2025 at a single center. Aneurysms were classified as small (<i>n</i> = 28) or very small (<i>n</i> = 8). Patient demographics, aneurysm characteristics, procedural details, angiographic outcomes, clinical outcomes, and complications were analyzed.ResultsMedian patient age was 57 years (IQR 43-73); 33.3% were male. The mean aneurysm dome height was 2.6 ± 0.9 mm, the mean neck diameter was 2.4 ± 0.7 mm, and the median dome-to-neck ratio was 1.0. Immediate complete occlusion (Raymond-Roy Class I) was achieved in 42.7% of aneurysms, and residual neck filling (Raymond-Roy Class II) in 25.0%. Follow-up imaging (mean 4.9 months) showed complete occlusion in 37.5% of aneurysms. Recanalization occurred in 29.2% of patients with repeat imaging and 6 (25%) requiring retreatment. Favorable clinical outcomes (mRS 0-2) occurred in 75.0%. Procedural complications occurred in 13.9% (five cases), including two intraprocedural perforations. No rebleeding occurred.ConclusionEarly experience with TTDC demonstrates safe, effective embolization for ruptured small and very small intracranial aneurysms, supporting the broader use of modern coils in these challenging lesions.</p>\",\"PeriodicalId\":14380,\"journal\":{\"name\":\"Interventional Neuroradiology\",\"volume\":\" \",\"pages\":\"15910199251351735\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Interventional Neuroradiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15910199251351735\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interventional Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15910199251351735","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景:小(< 5mm)和非常小(≤3mm)颅内破裂动脉瘤的血管治疗在技术上仍然具有挑战性,历史上具有较高的手术风险。线圈技术的进步,如Target Tetra可拆卸线圈(TTDC),旨在提高栓塞的安全性和有效性。然而,关于使用TTDC线圈专门治疗破裂动脉瘤的结果的数据有限。目的评价TTDC治疗颅内小、极小破裂动脉瘤的安全性、血管造影疗效及临床效果。方法回顾性分析2023 ~ 2025年在单中心使用TTDC治疗的36例≤5mm颅内动脉瘤破裂患者。动脉瘤分为小动脉瘤(n = 28)和极小动脉瘤(n = 8)。分析患者人口统计学、动脉瘤特征、手术细节、血管造影结果、临床结果和并发症。结果患者年龄中位数为57岁(IQR 43-73);33.3%为男性。动脉瘤穹窿平均高度为2.6±0.9 mm,平均颈径为2.4±0.7 mm,中位穹窿/颈比为1.0。42.7%的动脉瘤获得立即完全闭塞(Raymond-Roy Class I), 25.0%的动脉瘤获得残留颈部填充(Raymond-Roy Class II)。随访影像(平均4.9个月)显示37.5%的动脉瘤完全闭塞。29.2%的重复显像患者出现再通,6例(25%)需要再治疗。75.0%的患者临床预后良好(mRS 0-2)。术中并发症5例(13.9%),其中术中穿孔2例。无再出血发生。结论TTDC的早期经验表明,对于破裂的小动脉瘤和非常小的颅内动脉瘤,TTDC栓塞是安全有效的,支持现代线圈在这些具有挑战性的病变中的广泛应用。
Early experience with Target Tetra coils for treatment of small and very small ruptured intracranial aneurysms.
BackgroundEndovascular treatment of small (< 5 mm) and very small (≤ 3 mm) ruptured intracranial aneurysms remains technically challenging, historically carrying elevated procedural risks. Advances in coil technology, such as the Target Tetra Detachable Coil (TTDC), aim to improve embolization safety and efficacy. However, limited data exist on outcomes using TTDC coils specifically for ruptured aneurysms.ObjectiveTo evaluate the safety, angiographic efficacy, and clinical outcomes of TTDC for small and very small ruptured intracranial aneurysms.MethodsWe retrospectively analyzed 36 patients with ruptured intracranial aneurysms ≤5 mm treated using TTDC between 2023 and 2025 at a single center. Aneurysms were classified as small (n = 28) or very small (n = 8). Patient demographics, aneurysm characteristics, procedural details, angiographic outcomes, clinical outcomes, and complications were analyzed.ResultsMedian patient age was 57 years (IQR 43-73); 33.3% were male. The mean aneurysm dome height was 2.6 ± 0.9 mm, the mean neck diameter was 2.4 ± 0.7 mm, and the median dome-to-neck ratio was 1.0. Immediate complete occlusion (Raymond-Roy Class I) was achieved in 42.7% of aneurysms, and residual neck filling (Raymond-Roy Class II) in 25.0%. Follow-up imaging (mean 4.9 months) showed complete occlusion in 37.5% of aneurysms. Recanalization occurred in 29.2% of patients with repeat imaging and 6 (25%) requiring retreatment. Favorable clinical outcomes (mRS 0-2) occurred in 75.0%. Procedural complications occurred in 13.9% (five cases), including two intraprocedural perforations. No rebleeding occurred.ConclusionEarly experience with TTDC demonstrates safe, effective embolization for ruptured small and very small intracranial aneurysms, supporting the broader use of modern coils in these challenging lesions.
期刊介绍:
Interventional Neuroradiology (INR) is a peer-reviewed clinical practice journal documenting the current state of interventional neuroradiology worldwide. INR publishes original clinical observations, descriptions of new techniques or procedures, case reports, and articles on the ethical and social aspects of related health care. Original research published in INR is related to the practice of interventional neuroradiology...