区域选择性双脱水环化途径构建由2,3-二氢喹唑啉-4(1H)- 1和1,2-二氢吡咯[1,2-a]吡嗪组成的多杂环骨架。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-09 DOI:10.1039/d5ob00580a

Dohui Ku , Seoyoung Song , Ikyon Kim

引用次数: 0

摘要

Sc(OTf)3催化2-氨基苯甲酰胺与n-取代吡咯-2-甲醛的反应进行得很好，通过区域选择性双环脱水得到由二氢喹啉-4- 1和1,2-二氢吡咯[1,2-a]吡嗪组成的四环骨架，其中两个杂环（喹唑啉酮和吡嗪）通过形成三个C-N键依次构建。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Regioselective double dehydrative cyclization route to construct polyheterocyclic skeletons consisting of 2,3-dihydroquinazolin-4(1H)-ones and 1,2-dihydropyrrolo[1,2-a]pyrazines†

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Regioselective double dehydrative cyclization route to construct polyheterocyclic skeletons consisting of 2,3-dihydroquinazolin-4(1H)-ones and 1,2-dihydropyrrolo[1,2-a]pyrazines†

The Sc(OTf)₃-catalyzed reaction of 2-aminobenzamide with N-substituted pyrrole-2-carboxaldehyde proceeded well to give a tetracyclic skeleton consisting of dihydroquinazolin-4-one and 1,2-dihydropyrrolo[1,2-a]pyrazine via regioselective double cyclodehydrations where two heterocyclic rings (quinazolinone and pyrazine) were sequentially constructed through the formation of three C–N bonds.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.