手性双环脯氨酸类似物的合成

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-06-18 DOI:10.1016/j.tet.2025.134792

Radosław Gaida , Adam Włodarczyk , Marek Daszkiewicz , Elżbieta Wojaczyńska

引用次数: 0

摘要

制备了一系列由2-氮杂环[2.2.1]庚烷和2-氮杂环[2.2.2]辛烷衍生的双环脯氨酸类似物羧酸，并用x射线晶体学对5个衍生物进行了表征，得到的立体异构体具有明确的构型配位。测试了在肽合成中使用这些构建块的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of chiral bicyclic proline analogs

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Synthesis of chiral bicyclic proline analogs

A series of bicyclic proline analogs, carboxylic acids derived from 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[2.2.2]octane were prepared, and five derivatives were characterized by X-ray crystallography, which allowed unambiguous configurational assignment of obtained stereoisomers. The possibility to use of these building blocks in the synthesis of peptides was tested.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.