Georgios Soultanidis, Joaquin L. Herraiz, Zahi A. Fayad, Jan Grimm, Abraham J. P. Teunissen
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Nuclear imaging provides non-invasive and near-quantitative insight into the biodistribution of radiolabelled compounds, and it does so with exceptional sensitivity and practically unlimited penetration depth. These properties make nuclear imaging highly valuable for monitoring the pharmacokinetics, biodistribution and in vivo stability of therapeutics. Moreover, the diversity of radioactive probes allows for detailed insight into cell dynamics, metabolism, epigenetics and other biological processes. However, nuclear imaging remains largely limited to single-tracer studies, or to the sequential imaging of each tracer. Tracking only a single probe or compound at a time limits the insight that can be gained. Here we discuss the applications and clinical feasibility of established and upcoming strategies for the simultaneous imaging of multiple radiotracers.
期刊介绍:
Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.