血液学参数和炎症指标在判断阻塞性睡眠呼吸暂停综合征严重程度中的作用:现实还是神话?

Ayşe Seçil Kayali Dinç, Nagihan Gülhan Yaşar, Agah Yeniçeri, İrem Ağgünlü, Nurcan Yurtsever Kum, Melih Çayönü
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引用次数: 0

摘要

目的:阻塞性睡眠呼吸暂停综合征(OSAS)影响了相当一部分成年人,慢性炎症在其病理生理中起着至关重要的作用。本研究旨在探讨血液参数和炎症指标预测OSAS严重程度的有效性。方法:2009年12月至2024年12月期间就诊的OSAS患者纳入研究。根据多导睡眠图结果确定OSAS严重程度。记录住院期间的血液参数。根据血液参数计算以下血液学指标:中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、全身免疫炎症指数(SII)、预后营养指数(PNI)、泛免疫炎症值(PIV)、血红蛋白、白蛋白、淋巴细胞和血小板(HALP)指数。此外,研究了这些血液学参数和指标在判断OSAS严重程度中的潜在作用。结果:共纳入1009例患者。其中单纯性打鼾106例,轻度osaas 214例,中度osaas 224例,重度osaas 465例。OSAS严重程度与白蛋白水平、血红蛋白水平、白细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、δ中性粒细胞指数(DNI)等血液指标无显著相关性(p值分别为0.083、0.483、0.347、0.555、0.878、0.220、0.459)。此外,OSAS严重程度与NLR、PLR、SII、PNI、PIV、HALP指数等血液学炎症指标无显著相关性(p值分别为0.919、0.369、0.701、0.581、0.397、0.503)。结论:炎症过程参与了OSAS的病理生理过程;然而,本研究显示OSAS严重程度与血液学炎症指标之间没有关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of hematological parameters and inflammatory indices in determining the severity of obstructive sleep apnea syndrome: reality or myth?

Purpose: Obstructive sleep apnea syndrome (OSAS) affects a substantial portion of the adult population, and chronic inflammation plays a crucial role in its pathophysiology. This study aimed to investigate the effectiveness of blood parameters and inflammatory indices in predicting OSAS severity.

Methods: Patients diagnosed with OSAS who presented to our clinic between December 2009 and December 2024 were included in the study. OSAS severity was determined based on polysomnography results. Blood parameters obtained during hospitalization were recorded. The following hematological indices were calculated from blood parameters: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), prognostic nutritional index(PNI), pan-immune-inflammation value (PIV), and hemoglobin, albumin, lymphocyte, and platelet (HALP) index. Moreover, the potential role of these hematological parameters and indices in determining OSAS severity was investigated.

Results: A total of 1009 patients were included in the study. Among them, 106 had simple snoring, 214 had mild OSAS, 224 had moderate OSAS, and 465 had severe OSAS. No significant association was observed between OSAS severity and blood parameters, including albumin level, hemoglobin level, leukocyte count, neutrophil count, lymphocyte count, and platelet count, delta neutrophil index (DNI) (p-values: 0.083, 0.483, 0.347, 0.555, 0.878, 0.220, 0.459, respectively). Additionally, no significant correlation was observed between OSAS severity and hematological inflammatory indices such as NLR, PLR, SII, PNI, PIV, and HALP Index (p-values: 0.919, 0.369, 0.701, 0.581, 0.397, 0.503, respectively).

Conclusion: Inflammatory processes play a role in the pathophysiology of OSAS; however, the present study revealed no relationship between OSAS severity and hematological inflammatory indices.

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