Lifan Yang MD , Zilong Weng MB , Shasha Chen MD , Yuan Zhang MD , Daxin Zhou MD , Wenzhi Pan MD , Junbo Ge MD
{"title":"经导管主动脉瓣置换术治疗主动脉返流的非冠状动脉窦枢轴植入术。","authors":"Lifan Yang MD , Zilong Weng MB , Shasha Chen MD , Yuan Zhang MD , Daxin Zhou MD , Wenzhi Pan MD , Junbo Ge MD","doi":"10.1016/j.jacasi.2025.04.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Our initial study suggested that patients undergoing transcatheter aortic valve replacement (TAVR) with a self-expanding valve for pure native aortic regurgitation (PNAR) had a lower rate of major adverse cardiac events (MACE) when the noncoronary sinus pivot implantation (NCPI) was achieved.</div></div><div><h3>Objectives</h3><div>This study enrolled patients with PNAR who underwent TAVR with self-expanding valves between January 2019 and April 2024, compared the NCPI strategy with the conventional approach, and analyzed factors associated with successful NCPI.</div></div><div><h3>Methods</h3><div>We divided 87 patients into an early (conventional) group of patients treated before February 2023 and a late (NCPI strategy) group of patients treated after February 2023. Then the patients were also categorized by successful NCPI and non-NCPI group.</div></div><div><h3>Results</h3><div>The late group had significantly higher device success rates than the early group (92.9% vs 73.3%; <em>P =</em> 0.016) and lower rates of MACE (19.5% vs 51.1%; <em>P =</em> 0.002) and valve-in-valve implantation (4.8% vs 24.4%; <em>P =</em> 0.01). Importantly, NCPI was achieved in 90.5% of patients in the late group compared with only 17.8% in the early group (<em>P <</em> 0.001). The NCPI group had a higher device success rate (93.5% vs 70.7%; <em>P =</em> 0.005) and lower MACE rate (17.4%vs 56.1%; <em>P</em> < 0.001) than the non-NCPI group. NCPI (OR: 6.71; <em>P =</em> 0.032) and aortic angulation (OR: 1.07; <em>P =</em> 0.035) were independent predictors of device success.</div></div><div><h3>Conclusions</h3><div>NCPI strategy could be a general method used in TAVR with a self-expanding valve for patients with PNAR, which had a higher device success rate and lower rate of complications than the conventional method.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. 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Then the patients were also categorized by successful NCPI and non-NCPI group.</div></div><div><h3>Results</h3><div>The late group had significantly higher device success rates than the early group (92.9% vs 73.3%; <em>P =</em> 0.016) and lower rates of MACE (19.5% vs 51.1%; <em>P =</em> 0.002) and valve-in-valve implantation (4.8% vs 24.4%; <em>P =</em> 0.01). Importantly, NCPI was achieved in 90.5% of patients in the late group compared with only 17.8% in the early group (<em>P <</em> 0.001). The NCPI group had a higher device success rate (93.5% vs 70.7%; <em>P =</em> 0.005) and lower MACE rate (17.4%vs 56.1%; <em>P</em> < 0.001) than the non-NCPI group. NCPI (OR: 6.71; <em>P =</em> 0.032) and aortic angulation (OR: 1.07; <em>P =</em> 0.035) were independent predictors of device success.</div></div><div><h3>Conclusions</h3><div>NCPI strategy could be a general method used in TAVR with a self-expanding valve for patients with PNAR, which had a higher device success rate and lower rate of complications than the conventional method.</div></div>\",\"PeriodicalId\":73529,\"journal\":{\"name\":\"JACC. Asia\",\"volume\":\"5 7\",\"pages\":\"Pages 884-894\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JACC. 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引用次数: 0
摘要
背景:我们的初步研究表明,接受经导管主动脉瓣置换术(TAVR)和自扩张瓣膜治疗纯原生主动脉瓣返流(PNAR)的患者在实现非冠状动脉窦枢轴植入(NCPI)后,发生主要心脏不良事件(MACE)的几率较低。目的:本研究纳入2019年1月至2024年4月期间接受自扩瓣膜TAVR的PNAR患者,比较NCPI策略与传统方法,并分析NCPI成功的相关因素。方法:将87例患者分为2023年2月前治疗的早期(常规)组和2023年2月后治疗的晚期(NCPI策略)组。然后将患者分为NCPI成功组和非NCPI组。结果:晚期组器械成功率明显高于早期组(92.9% vs 73.3%;P = 0.016), MACE发生率较低(19.5% vs 51.1%;P = 0.002)和瓣中植入(4.8% vs 24.4%;P = 0.01)。重要的是,晚期组90.5%的患者达到了NCPI,而早期组只有17.8% (P < 0.001)。NCPI组器械成功率更高(93.5% vs 70.7%;P = 0.005)和较低的MACE率(17.4%vs 56.1%;P < 0.001)高于非ncpi组。Ncpi (or: 6.71;P = 0.032)和主动脉成角(OR: 1.07;P = 0.035)是器械成功的独立预测因子。结论:NCPI策略可作为PNAR患者自扩瓣膜TAVR的通用方法,其装置成功率高于常规方法,并发症发生率低于常规方法。
Noncoronary Sinus Pivot Implantation for Transcatheter Aortic Valve Replacement With Self-Expanding Valve for Aortic Regurgitation
Background
Our initial study suggested that patients undergoing transcatheter aortic valve replacement (TAVR) with a self-expanding valve for pure native aortic regurgitation (PNAR) had a lower rate of major adverse cardiac events (MACE) when the noncoronary sinus pivot implantation (NCPI) was achieved.
Objectives
This study enrolled patients with PNAR who underwent TAVR with self-expanding valves between January 2019 and April 2024, compared the NCPI strategy with the conventional approach, and analyzed factors associated with successful NCPI.
Methods
We divided 87 patients into an early (conventional) group of patients treated before February 2023 and a late (NCPI strategy) group of patients treated after February 2023. Then the patients were also categorized by successful NCPI and non-NCPI group.
Results
The late group had significantly higher device success rates than the early group (92.9% vs 73.3%; P = 0.016) and lower rates of MACE (19.5% vs 51.1%; P = 0.002) and valve-in-valve implantation (4.8% vs 24.4%; P = 0.01). Importantly, NCPI was achieved in 90.5% of patients in the late group compared with only 17.8% in the early group (P < 0.001). The NCPI group had a higher device success rate (93.5% vs 70.7%; P = 0.005) and lower MACE rate (17.4%vs 56.1%; P < 0.001) than the non-NCPI group. NCPI (OR: 6.71; P = 0.032) and aortic angulation (OR: 1.07; P = 0.035) were independent predictors of device success.
Conclusions
NCPI strategy could be a general method used in TAVR with a self-expanding valve for patients with PNAR, which had a higher device success rate and lower rate of complications than the conventional method.