早期口腔舌鳞癌侵袭性肿瘤前缘肿瘤出芽的临床病理相关性：组织学和免疫组织化学分析。

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-06-19 DOI:10.1002/hed.28204

Samuel Espías Alonso, Francisco Alijo Serrano, Ignacio Navarro Cuéllar, Ana López López, Diego Fernández Acosta, Borja González Moure, José Zamorano León, Carlos Navarro Cuéllar

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引用次数: 0

摘要

背景：舌头鳞状细胞癌（SCC）的肿瘤出芽（TB）的特征是在侵袭性肿瘤前部出现分离的肿瘤细胞或细胞簇。方法：本研究（n = 61）旨在分析TB的诊断方法学、肿瘤特征与TB的关系、免疫组化特征及其与TB指数（TBI）的相关性，评估TB与宫颈转移相关的预后因素，分析无病生存期（DFS）和总生存期（OS）。结果：结核与浸润深度（DOI）、神经周围浸润、E-Cadherin表达、Ki-67指数有统计学意义。宫颈转移与DOI、神经周围浸润、TBI、E-Cadherin表达、Ki-67指数有统计学意义。结论：结核与DOI及神经周围浸润有显著相关性。高TBI患者与E-cadherin表达降低和Ki-67指数升高相关。TBI是宫颈淋巴转移存在的独立预后因素，未发现TBI与DFS或OS之间存在关联。

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Clinicopathological Relevance of Tumor Budding at the Invasive Tumor Front in Early-Stage Oral Tongue Squamous Cell Carcinoma: Histological and Immunohistochemical Analysis.

Background: Tumor budding (TB) is characterized by isolated tumor cells or cell clusters at the invasive tumor front in squamous cell carcinoma (SCC) of the tongue.

Methods: This research (n = 61) aimed to analyze the diagnostic methodology of TB, the association between the tumoral features and TB, the immunohistochemical characteristics and their correlation with the TB index (TBI), assess the prognostic factors of TB in relation to cervical metastases and analyze disease-free survival (DFS) and overall survival (OS).

Results: A statistically significant association was found between TB and depth of invasion (DOI), perineural invasion, E-Cadherin expression, and Ki-67 index. Regarding cervical metastases, a statistically significant association was observed with DOI, perineural invasion, TBI, E-Cadherin expression, and Ki-67 index.

Conclusions: TB correlates significantly with DOI and perineural invasion. Patients with a high TBI are associated with decreased E-cadherin expression and an increased Ki-67 index. TBI is an independent prognostic factor for the presence of cervical lymphatic metastases, and no association was found between the TBI and DFS or OS.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.