传统抗癫痫药物治疗失败时应考虑的非传统抗癫痫药物:治疗难治性癫痫和癫痫的药物。

Q2 Medicine
Adrian Turner, M Scott Perry
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引用次数: 0

摘要

在癫痫领域,精准医学的出现和药物的新用途的改变,偶然地使更准确的诊断和个体化靶向治疗成为可能。尽管取得了这些进展,但仍然有一些患者对传统的处方治疗没有充分的反应,或者根本没有反应。当大多数(如果不是全部的话)抗癫痫治疗没有产生足够的效果时,临床医生通常需要有创造力,利用临床经验和严格的研究来直觉下一步。在此,我们描述了5种由合著者临床经验和处方者在临床实践中确定的用于药物信息目的的有效控制癫痫发作的药物(例如,氯胺酮,美金刚,奎尼丁,利鲁唑,曲唑酮)。此外,我们总结了相关的药代动力学、不良反应以及与神经学药物的已知和潜在相互作用,以进一步指导临床应用。氯胺酮和美金刚似乎是目前应用于患者的有希望的选择,而奎尼丁、利鲁唑和曲唑酮的数据可能有助于未来在特定患者群体中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nontraditional Antiseizure Medications to Consider When Traditional Options Have Failed: Medications for Refractory Seizures and Epilepsies.

In the field of epilepsy, the advent of precision medicine and the repurposing of medications for new applications have fortuitously allowed more accurate diagnosing and individually targeted therapeutics. Despite these advances, there remain patients who do not respond sufficiently-or at all-to traditionally prescribed treatments. Clinicians often need to be creative, using clinical experience and rigorous research to intuit the next step when most, if not all, anti-seizure treatments have not produced sufficient results. Herein we describe 5 medications with emerging reports of efficacy for seizure control identified by coauthor clinical experience and prescribers in clinical practice for drug information purposes (e.g., ketamine, memantine, quinidine, riluzole, trazodone). Additionally, we summarize pertinent pharmacokinetics, adverse effects, and known and potential interactions with neurologically focused medications to further guide clinical application. Ketamine and memantine appear to be promising options to apply to patients presently, while quinidine, riluzole, and trazodone have data that could contribute to future applications in specific patient populations.

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来源期刊
Journal of Pediatric Pharmacology and Therapeutics
Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.40
自引率
0.00%
发文量
90
期刊介绍: The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.
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