Zhenyi Niu, Feng Zhu, Yuqin Cao, Congcong Luo, Dan Liu, Chunping Wang, Zhenbin Qiu, Lishan Peng, Mingyuan Du, Runsen Jin, Yan Yan, Dong Dong, Hui Jing, Xiaofeng Wang, Wei Guo, Zengya Guo, Chengqiang Li, Dingpei Han, Yajie Zhang, Jie Xiang, Hailei Du, Kai Chen, Zhengxin Yin, Jie Yang, Wenzhao Zhong, Yongxin Zhou, Mingsong Wang, Dongchun Ma, Hecheng Li
{"title":"2019冠状病毒病对早期肺癌患者手术的影响：covid - lung - surg前瞻性队列研究","authors":"Zhenyi Niu, Feng Zhu, Yuqin Cao, Congcong Luo, Dan Liu, Chunping Wang, Zhenbin Qiu, Lishan Peng, Mingyuan Du, Runsen Jin, Yan Yan, Dong Dong, Hui Jing, Xiaofeng Wang, Wei Guo, Zengya Guo, Chengqiang Li, Dingpei Han, Yajie Zhang, Jie Xiang, Hailei Du, Kai Chen, Zhengxin Yin, Jie Yang, Wenzhao Zhong, Yongxin Zhou, Mingsong Wang, Dongchun Ma, Hecheng Li","doi":"10.21037/tlcr-2024-1276","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Previous studies found that preoperative coronavirus disease 2019 (COVID-19) was associated with higher risk of postoperative complications. A seven-to-eight week delay of surgery was recommended for patients with newly diagnosed COVID-19. However, given the widespread vaccination and less virulent variant, the timing of surgery after COVID-19 requires further evaluation. This study was conducted to investigate the impact of COVID-19 on early-stage lung cancer patients undergoing surgery.</p><p><strong>Methods: </strong>We conducted this prospective cohort study of COVID-19 lung surgery (COVIDLungSurg) in five hospitals in China between January 2023 and April 2024. Early-stage lung cancer patients who underwent surgery were included in this study. The primary outcome was the rate of postoperative complication within the first postoperative 30 days. The secondary outcomes included total length of hospital stay, postoperative stay, and 30-day mortality. Adjusted analyses were performed using propensity score matching and logistic regression models. This study was registered at ClinicalTrials.gov (NCT05684549).</p><p><strong>Results: </strong>Of the 1,734 patients included in our study, 1,496 had preoperative COVID-19. A total of 1,538 patients were fully vaccinated against COVID-19. The rate of postoperative complication was 9.5% (165/1,734) in all the included patients, with no significant difference in patients with and without history of COVID-19 [9.2% (137/1,496) <i>vs.</i> 11.8% (28/238), P=0.20]. Among patients with preoperative COVID-19, time since COVID-19 to surgery did not show any association with postoperative complications in the multivariable logistic regression model [odds ratio, 1.00; 95% confidence interval (CI): 0.99-1.01; P=0.41].</p><p><strong>Conclusions: </strong>In the Omicron predominant era, preoperative COVID-19 was not associated with higher risk of postoperative complications in early-stage lung cancer patients. The time between COVID-19 infection and surgery was not associated with postoperative complications.</p>","PeriodicalId":23271,"journal":{"name":"Translational lung cancer research","volume":"14 5","pages":"1677-1687"},"PeriodicalIF":3.5000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170135/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of coronavirus disease 2019 on surgery in patients with early-stage lung cancer: the COVIDLungSurg prospective cohort study.\",\"authors\":\"Zhenyi Niu, Feng Zhu, Yuqin Cao, Congcong Luo, Dan Liu, Chunping Wang, Zhenbin Qiu, Lishan Peng, Mingyuan Du, Runsen Jin, Yan Yan, Dong Dong, Hui Jing, Xiaofeng Wang, Wei Guo, Zengya Guo, Chengqiang Li, Dingpei Han, Yajie Zhang, Jie Xiang, Hailei Du, Kai Chen, Zhengxin Yin, Jie Yang, Wenzhao Zhong, Yongxin Zhou, Mingsong Wang, Dongchun Ma, Hecheng Li\",\"doi\":\"10.21037/tlcr-2024-1276\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Previous studies found that preoperative coronavirus disease 2019 (COVID-19) was associated with higher risk of postoperative complications. A seven-to-eight week delay of surgery was recommended for patients with newly diagnosed COVID-19. However, given the widespread vaccination and less virulent variant, the timing of surgery after COVID-19 requires further evaluation. This study was conducted to investigate the impact of COVID-19 on early-stage lung cancer patients undergoing surgery.</p><p><strong>Methods: </strong>We conducted this prospective cohort study of COVID-19 lung surgery (COVIDLungSurg) in five hospitals in China between January 2023 and April 2024. Early-stage lung cancer patients who underwent surgery were included in this study. The primary outcome was the rate of postoperative complication within the first postoperative 30 days. The secondary outcomes included total length of hospital stay, postoperative stay, and 30-day mortality. Adjusted analyses were performed using propensity score matching and logistic regression models. This study was registered at ClinicalTrials.gov (NCT05684549).</p><p><strong>Results: </strong>Of the 1,734 patients included in our study, 1,496 had preoperative COVID-19. A total of 1,538 patients were fully vaccinated against COVID-19. The rate of postoperative complication was 9.5% (165/1,734) in all the included patients, with no significant difference in patients with and without history of COVID-19 [9.2% (137/1,496) <i>vs.</i> 11.8% (28/238), P=0.20]. Among patients with preoperative COVID-19, time since COVID-19 to surgery did not show any association with postoperative complications in the multivariable logistic regression model [odds ratio, 1.00; 95% confidence interval (CI): 0.99-1.01; P=0.41].</p><p><strong>Conclusions: </strong>In the Omicron predominant era, preoperative COVID-19 was not associated with higher risk of postoperative complications in early-stage lung cancer patients. The time between COVID-19 infection and surgery was not associated with postoperative complications.</p>\",\"PeriodicalId\":23271,\"journal\":{\"name\":\"Translational lung cancer research\",\"volume\":\"14 5\",\"pages\":\"1677-1687\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170135/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational lung cancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21037/tlcr-2024-1276\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational lung cancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/tlcr-2024-1276","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Impact of coronavirus disease 2019 on surgery in patients with early-stage lung cancer: the COVIDLungSurg prospective cohort study.
Background: Previous studies found that preoperative coronavirus disease 2019 (COVID-19) was associated with higher risk of postoperative complications. A seven-to-eight week delay of surgery was recommended for patients with newly diagnosed COVID-19. However, given the widespread vaccination and less virulent variant, the timing of surgery after COVID-19 requires further evaluation. This study was conducted to investigate the impact of COVID-19 on early-stage lung cancer patients undergoing surgery.
Methods: We conducted this prospective cohort study of COVID-19 lung surgery (COVIDLungSurg) in five hospitals in China between January 2023 and April 2024. Early-stage lung cancer patients who underwent surgery were included in this study. The primary outcome was the rate of postoperative complication within the first postoperative 30 days. The secondary outcomes included total length of hospital stay, postoperative stay, and 30-day mortality. Adjusted analyses were performed using propensity score matching and logistic regression models. This study was registered at ClinicalTrials.gov (NCT05684549).
Results: Of the 1,734 patients included in our study, 1,496 had preoperative COVID-19. A total of 1,538 patients were fully vaccinated against COVID-19. The rate of postoperative complication was 9.5% (165/1,734) in all the included patients, with no significant difference in patients with and without history of COVID-19 [9.2% (137/1,496) vs. 11.8% (28/238), P=0.20]. Among patients with preoperative COVID-19, time since COVID-19 to surgery did not show any association with postoperative complications in the multivariable logistic regression model [odds ratio, 1.00; 95% confidence interval (CI): 0.99-1.01; P=0.41].
Conclusions: In the Omicron predominant era, preoperative COVID-19 was not associated with higher risk of postoperative complications in early-stage lung cancer patients. The time between COVID-19 infection and surgery was not associated with postoperative complications.
期刊介绍：
Translational Lung Cancer Research(TLCR, Transl Lung Cancer Res, Print ISSN 2218-6751; Online ISSN 2226-4477) is an international, peer-reviewed, open-access journal, which was founded in March 2012. TLCR is indexed by PubMed/PubMed Central and the Chemical Abstracts Service (CAS) Databases. It is published quarterly the first year, and published bimonthly since February 2013. It provides practical up-to-date information on prevention, early detection, diagnosis, and treatment of lung cancer. Specific areas of its interest include, but not limited to, multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to lung cancer.
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