[自闭症谱系障碍儿童听觉脑干反应登记指标]。

Q3 Medicine
A V Pashkov, M T Fatakhova, N V Ustinova, L S Namazova-Baranova, I V Naumova, V G Kunitsyna, P A Rubinshtein, K I Voevodina, D S Chirkina, A M Mamedyarov
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引用次数: 0

摘要

目的:比较2 ~ 3岁自闭症谱系障碍(ASD)儿童听觉脑干反应(ABR)各成分的潜伏期。材料与方法:本研究包括12名确诊为ASD的儿童的研究结果,其中男孩9名,女孩3名,年龄24 - 33个月。为了评估所有儿童的听觉功能,用宽带点击作为刺激的听觉脑干反应来记录。在研究的第一阶段,我们确定了ABR记录的阈值,以排除听力损失的存在。有听力障碍的儿童(4人)不包括在研究中,他们被分配到一个单独的组进行进一步观察。研究的第二阶段是对无听力障碍的ASD患者和正常发育儿童的V波潜伏期进行比较分析。结果:自闭症谱系障碍儿童组V波潜伏期平均值为6.34 ms (Mann-Whitney u检验,p≥0.05有增长趋势,无统计学意义),正常为6.75 ~ 6.90 ms。标准差为0.4(6.37%)。讨论:潜伏期指标对ABR刺激筛选值的偏离可视为自闭症谱系障碍的生物标志物。排除或确认有这些变化的ASD儿童应咨询专业专家。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Indicators of registration of auditory brainstem responses in children with autism spectrum disorder].

Objective: To evaluate the latency of the components of the auditory brainstem responses (ABR) in children with autism spectrum disorder (ASD) in age 2-3 years in comparison with the norm.

Material and methods: The research includes the results of studies of 12 children with a confirmed diagnosis of ASD, including 9 boys and 3 girls aged 24 to 33 months. To assess the auditory function all children were recorded using auditory brainstem responses with a broadband click as a stimulus. At the first stage of the study, we determined the threshold of ABR recording to exclude the presence of hearing loss. Children with hearing disorders (4 people) were not included in the study - they were allocated to a separate group for further observation. The second stage of the study was a comparative analysis of the latency of wave V in patients with ASD without hearing impairment and children with normotypic development.

Results: The average latency value of the wave V in the group of children with autism spectrum disorders was 6.34 ms (Mann-Whitney U-test, p≥0.05 with a growth trend, indicating a lack of statistical significance), normally 6.75-6.90 ms. The standard deviation was 0.4 (6.37%).

Discussion: The deviation of latency indicators from the norm on the screening values of the ABR stimulus can be considered a biomarker of autism spectrum disorders. To exclude or confirm ASD children with such changes should be referred for consultation to specialized specialists.

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来源期刊
Vestnik otorinolaringologii
Vestnik otorinolaringologii Medicine-Otorhinolaryngology
CiteScore
0.80
自引率
0.00%
发文量
69
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