静脉注射免疫球蛋白和脂质乳治疗生殖衰竭伴NK细胞异常的比较研究。

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2025-06-18 eCollection Date: 2025-01-01 DOI:10.1002/rmb2.12662

Ayano Yamaya, Atsushi Fukui, Kiyotaka Kawai, Mizuho Yano, Haruka Honda, Kohei Nakagawa, Hidetake Kamei, Maya Omote, Yu Wakimoto, Seiji Mabuchi

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引用次数: 0

摘要

目的：比较静脉注射免疫球蛋白（IVIG）和脂质乳（LE）治疗与自然杀伤细胞（NK）异常相关的复发性妊娠丢失（RPL）和复发性着床失败（RIF）等生殖衰竭的疗效。方法：外周血NK （pNK）细胞活性≥40%，子宫CD16+/CD56dim NK （uNK）细胞活性≥18%为NK细胞异常。RPL和RIF患者分别给予IVIG和LE。IVF-ET患者分别在ET前、ET当天和ET后进行治疗。结果：IVIG组和LE组植入率分别为48.3%和47.8%，差异无统计学意义。对于RPL患者，IVIG组和LE组的活产率分别为75.0%和72.5%，差异无统计学意义。对于ET前、ET当天、ET后给药时间，IVIG组临床妊娠率分别为47.6%、0%、0%，LE组临床妊娠率分别为30.0%、12.5%、0%。结论：两种治疗方法对与NK细胞异常相关的生殖疾病的治疗效果相当。

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A Comparative Study of Intravenous Immunoglobulin and Lipid Emulsion in Patients With Reproductive Failures Associated With NK Cell Abnormalities.

Purpose: To compare the effects of intravenous immunoglobulin (IVIG) and lipid emulsion (LE) therapies on reproductive failure such as recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) associated with natural killer (NK) cell abnormalities.

Methods: NK cell abnormalities were defined as peripheral blood NK (pNK) cell activity of 40% or higher and CD16⁺/CD56^dim uterine NK (uNK) cells at 18% or higher. IVIG and LE were administered to RPL and RIF patients. In patients undergoing IVF-ET, treatment was initiated either before ET, on ET day, or after ET.

Results: Implantation rates of 48.3% and 47.8% were revealed in the IVIG and LE groups, respectively, with no significant difference. For patients with RPL, live birth rates were 75.0% for the IVIG group and 72.5% for the LE group, with no significant difference. For timings of administration before ET, on ET day, or after ET, the clinical pregnancy rates were 47.6%, 0%, and 0%, respectively, in the IVIG group and 30.0%, 12.5%, and 0%, respectively, in the LE group. Higher clinical pregnancy rates were observed when each treatment was initiated before ET.

Conclusions: Both treatments exhibited comparable therapeutic effects on reproductive disorders associated with NK cell abnormalities.

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.