儿童肺移植术后与健康相关的生活质量

IF 2.7 3区 医学 Q1 PEDIATRICS
Nicole Martin, Edith Nachbaur, Zsolt Szépfalusi, Dóra Krikovsky, Lajos Kovács, Clemens Aigner, Konrad Hoetzenecker, Alberto Benazzo, Peter Jaksch, Alexandra Graf, Saskia Gruber
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引用次数: 0

摘要

背景:儿童肺移植是儿童和青少年终末期肺病的一种治疗选择。虽然它提供了延长生存和改善身体健康的机会,但对健康相关生活质量(HRQOL)的影响仍未得到充分研究。方法:本观察性研究旨在评估儿童肺移植受者的HRQOL,使用EuroQol问卷和额外的自我设计的问题,如学校、就业和住房情况。我们将结果与患有终末期肺病的儿童和青少年的结果进行了比较,并调查了可能的影响因素。患者在移植后至少2个月开始进行常规临床访问。数据收集时间为2016年11月至2023年1月。结果:该研究纳入了29例首次肺移植时年龄在4至17岁之间的儿童肺移植受者。我们的研究结果显示,儿童肺移植术后HRQOL良好,euroqol评分中位数为1.0,代表了最好的euroqol评分,视觉模拟评分(VAS)中位数为93分(满分100分)。大多数患者从事就业或教育,他们通常与父母住在一起。HRQOL优于移植前终末期肺病患者,提示肺移植可改善患者的生活质量。存在慢性同种异体肺移植功能障碍(chronic lung allograft dysfunction, CLAD)、移植年龄较低、移植后时间较长与较低的HRQOL评分相关。结论:本研究强调了儿童肺移植受者普遍良好的HRQOL。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Health-Related Quality of Life After Pediatric Lung Transplantation.

Background: Pediatric lung transplantation is a therapeutic option for children and adolescents with end-stage lung disease. While it offers a chance to extend survival and improve physical health, the impact on health-related quality of life (HRQOL) remains understudied.

Methods: This observational study aimed to assess HRQOL in pediatric lung transplant recipients using the EuroQol questionnaire and additional self-designed questions about school, employment, and housing situations. We compared the results to those in children and adolescents with end-stage lung disease and investigated possible influencing determinants. Patients were included during routine clinical visits, starting at least 2 months post-transplant. Data collection was from November 2016 to January 2023.

Results: The study included 29 pediatric lung transplant recipients aged between 4 and 17 years at the time of first transplantation. Our findings show a good HRQOL after pediatric lung transplantation with a median EuroQol-Score of 1.0, representing the best possible EuroQol-Score, and a median visual analog scale (VAS) score of 93 out of 100. Most patients were engaged in employment or education, and they typically lived with their parents. HRQOL was superior to that of pre-transplant patients with end-stage lung disease, suggesting a quality of life improvement by lung transplantation. The presence of chronic lung allograft dysfunction (CLAD), a lower age at transplantation, and a longer time since transplantation were associated with lower HRQOL scores.

Conclusion: This study underscores the generally favorable HRQOL experienced by pediatric lung transplant recipients.

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来源期刊
Pediatric Pulmonology
Pediatric Pulmonology 医学-呼吸系统
CiteScore
6.00
自引率
12.90%
发文量
468
审稿时长
3-8 weeks
期刊介绍: Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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