Nicole Martin, Edith Nachbaur, Zsolt Szépfalusi, Dóra Krikovsky, Lajos Kovács, Clemens Aigner, Konrad Hoetzenecker, Alberto Benazzo, Peter Jaksch, Alexandra Graf, Saskia Gruber
{"title":"儿童肺移植术后与健康相关的生活质量","authors":"Nicole Martin, Edith Nachbaur, Zsolt Szépfalusi, Dóra Krikovsky, Lajos Kovács, Clemens Aigner, Konrad Hoetzenecker, Alberto Benazzo, Peter Jaksch, Alexandra Graf, Saskia Gruber","doi":"10.1002/ppul.71157","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pediatric lung transplantation is a therapeutic option for children and adolescents with end-stage lung disease. While it offers a chance to extend survival and improve physical health, the impact on health-related quality of life (HRQOL) remains understudied.</p><p><strong>Methods: </strong>This observational study aimed to assess HRQOL in pediatric lung transplant recipients using the EuroQol questionnaire and additional self-designed questions about school, employment, and housing situations. We compared the results to those in children and adolescents with end-stage lung disease and investigated possible influencing determinants. Patients were included during routine clinical visits, starting at least 2 months post-transplant. Data collection was from November 2016 to January 2023.</p><p><strong>Results: </strong>The study included 29 pediatric lung transplant recipients aged between 4 and 17 years at the time of first transplantation. Our findings show a good HRQOL after pediatric lung transplantation with a median EuroQol-Score of 1.0, representing the best possible EuroQol-Score, and a median visual analog scale (VAS) score of 93 out of 100. Most patients were engaged in employment or education, and they typically lived with their parents. HRQOL was superior to that of pre-transplant patients with end-stage lung disease, suggesting a quality of life improvement by lung transplantation. The presence of chronic lung allograft dysfunction (CLAD), a lower age at transplantation, and a longer time since transplantation were associated with lower HRQOL scores.</p><p><strong>Conclusion: </strong>This study underscores the generally favorable HRQOL experienced by pediatric lung transplant recipients.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71157"},"PeriodicalIF":2.7000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178106/pdf/","citationCount":"0","resultStr":"{\"title\":\"Health-Related Quality of Life After Pediatric Lung Transplantation.\",\"authors\":\"Nicole Martin, Edith Nachbaur, Zsolt Szépfalusi, Dóra Krikovsky, Lajos Kovács, Clemens Aigner, Konrad Hoetzenecker, Alberto Benazzo, Peter Jaksch, Alexandra Graf, Saskia Gruber\",\"doi\":\"10.1002/ppul.71157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Pediatric lung transplantation is a therapeutic option for children and adolescents with end-stage lung disease. While it offers a chance to extend survival and improve physical health, the impact on health-related quality of life (HRQOL) remains understudied.</p><p><strong>Methods: </strong>This observational study aimed to assess HRQOL in pediatric lung transplant recipients using the EuroQol questionnaire and additional self-designed questions about school, employment, and housing situations. We compared the results to those in children and adolescents with end-stage lung disease and investigated possible influencing determinants. Patients were included during routine clinical visits, starting at least 2 months post-transplant. Data collection was from November 2016 to January 2023.</p><p><strong>Results: </strong>The study included 29 pediatric lung transplant recipients aged between 4 and 17 years at the time of first transplantation. Our findings show a good HRQOL after pediatric lung transplantation with a median EuroQol-Score of 1.0, representing the best possible EuroQol-Score, and a median visual analog scale (VAS) score of 93 out of 100. Most patients were engaged in employment or education, and they typically lived with their parents. HRQOL was superior to that of pre-transplant patients with end-stage lung disease, suggesting a quality of life improvement by lung transplantation. The presence of chronic lung allograft dysfunction (CLAD), a lower age at transplantation, and a longer time since transplantation were associated with lower HRQOL scores.</p><p><strong>Conclusion: </strong>This study underscores the generally favorable HRQOL experienced by pediatric lung transplant recipients.</p>\",\"PeriodicalId\":19932,\"journal\":{\"name\":\"Pediatric Pulmonology\",\"volume\":\"60 6\",\"pages\":\"e71157\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178106/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Pulmonology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ppul.71157\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Pulmonology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ppul.71157","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Health-Related Quality of Life After Pediatric Lung Transplantation.
Background: Pediatric lung transplantation is a therapeutic option for children and adolescents with end-stage lung disease. While it offers a chance to extend survival and improve physical health, the impact on health-related quality of life (HRQOL) remains understudied.
Methods: This observational study aimed to assess HRQOL in pediatric lung transplant recipients using the EuroQol questionnaire and additional self-designed questions about school, employment, and housing situations. We compared the results to those in children and adolescents with end-stage lung disease and investigated possible influencing determinants. Patients were included during routine clinical visits, starting at least 2 months post-transplant. Data collection was from November 2016 to January 2023.
Results: The study included 29 pediatric lung transplant recipients aged between 4 and 17 years at the time of first transplantation. Our findings show a good HRQOL after pediatric lung transplantation with a median EuroQol-Score of 1.0, representing the best possible EuroQol-Score, and a median visual analog scale (VAS) score of 93 out of 100. Most patients were engaged in employment or education, and they typically lived with their parents. HRQOL was superior to that of pre-transplant patients with end-stage lung disease, suggesting a quality of life improvement by lung transplantation. The presence of chronic lung allograft dysfunction (CLAD), a lower age at transplantation, and a longer time since transplantation were associated with lower HRQOL scores.
Conclusion: This study underscores the generally favorable HRQOL experienced by pediatric lung transplant recipients.
期刊介绍:
Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases.
PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.