儿科急诊科诊断为毛细支气管炎的儿童肠通透性评估:一项横断面研究。

IF 2.7 3区 医学 Q1 PEDIATRICS
Abdullah Akkuş, Ahmet Osman Kiliç, Fatih Ercan, Mehtap Yücel, Abdullah Yazar, Fatih Akin, Sevgi Pekcan, Hasan Çetin, Hanife Tuğçe Çağlar
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引用次数: 0

摘要

背景:毛细支气管炎是最常见的下呼吸道感染,最常见的分离生物是呼吸道合胞病毒(RSV)。尽管有一些关于各种急慢性肺部疾病的肠通透性的研究,但在毛细支气管炎患者中检测这些分子的研究非常有限。本研究旨在检测毛细支气管炎患儿的zonulin和claudin-3水平以评估肠通透性。材料与方法:本研究共纳入98例儿童、60例毛细支气管炎患者和38例健康对照。在征得患者及其父母知情同意后,于确诊入院时采集血清样本5 mL,冷冻保存,检测zonulin和claudin-3水平,并进行组间分析比较。结果:患者组zonulin的中位数为18.57 ng/mL,对照组为12.41 ng/mL。患者与对照组zonulin水平差异无统计学意义(p = 0.540)。患者组CLDN3(3889.56)明显低于对照组(4216.77),差异有统计学意义(p 0.05)。结论:毛细支气管炎患者CLDN3水平明显低于对照组。这一发现可能表明,低CLDN3水平可能通过损害气道通透性参与了毛细支气管炎的发病机制,进一步的研究是有必要的,研究气道通透性对毛细支气管炎发病机制的影响,根据疾病严重程度比较zonulin和CLDN3水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Intestinal Permeability in Children Diagnosed With Bronchiolitis in Pediatric Emergency Department: A Cross-Sectional Study.

Background: Bronchiolitis is the most common lower respiratory tract infection, with the most commonly isolated organism being respiratory syncytial virus (RSV). Despite several studies on intestinal permeability in various acute and chronic pulmonary diseases, studies examining these molecules in patients diagnosed with bronchiolitis are very limited. This study was conducted to examine zonulin and claudin-3 levels to evaluate intestinal permeability in children diagnosed with bronchiolitis.

Materials and methods: A total of 98 children, 60 patients with bronchiolitis and 38 healthy controls were included in this study. After informed consent of patients and their parents were obtained, 5 mL of blood serum samples were collected upon admission, after confirmation of the diagnosis, which were kept frozen until being analyzed for zonulin and claudin-3 levels and subsequently analyzed and compared between the groups.

Results: The median value of zonulin was 18.57 ng/mL in the patient group and 12.41 ng/mL in the control group. There was no significant difference in zonulin levels between the patient and control groups (p = 0.540). The mean claudin-3 (CLDN3) level was significantly lower in the patient group (3889.56) than the control group 4216.77 (p < 0.001). In the patient group, zonulin and claudin levels did not significantly differ by the need of mechanical ventilation and ICU administration (p > 0.05).

Conclusion: In conclusion, CLDN3 levels were found to be significantly lower in patients with bronchiolitis than in the control group. This finding may indicate that low CLDN3 levels may be involved in pathogenesis of bronchiolitis, by impairing airway permeability Further studies with larger number of participants, investigating the effect of airway permeability on the pathogenesis of bronchiolitis, which compare zonulin and CLDN3 levels according to disease severity, are warranted.

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来源期刊
Pediatric Pulmonology
Pediatric Pulmonology 医学-呼吸系统
CiteScore
6.00
自引率
12.90%
发文量
468
审稿时长
3-8 weeks
期刊介绍: Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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