{"title":"儿童结直肠癌的最新进展：系统综述。","authors":"Navdeep Dhoat, Shilpa Sharma","doi":"10.1007/s00383-025-06076-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To study the recent advances in Pediatric colorectal cancer (PCRC), including molecular profiling, clinical and genetic characteristics, screening guidelines, and treatment strategies.</p><p><strong>Method: </strong>A PubMed search was done on 25 March 2025, by using search words Pediatric colorectal cancer with a filter of last year, yielding 414 articles. On screening for relevant articles focusing on molecular profiles or screening guidelines in pediatric cases, 10 articles were selected, describing 38 tumors in 36 pediatric patients.</p><p><strong>Results: </strong>Clinical features of PCRC included unexplained abdominal pain, abdominal distension, vomiting, hematochezia, intestinal obstruction, and intestinal intussusception. Salient molecular profiling included distinct genomic landscapes in pediatric/ young adult CRC compared to adult CRC, and differences in WNT and PI3K-AKT pathways. PCRC had a significantly higher frequency of RNF43 mutations versus APC mutations in adults, suggesting age-related differences in WNT pathway activation. PCRC showed a peculiar profile with CDK6 amplification and enrichment of lysine degradation pathway. Few PCRC cases showed mismatch repair (MMR) deficiency, suggesting second-hit somatic alterations. The recent advances highlight in identifying hereditary cancer susceptibility syndromes and utility of indocyanine green fluorescence-guided surgery.</p><p><strong>Conclusion: </strong>Distinct molecular signatures in PCRC underscore the need for age-specific treatment strategies, multidisciplinary care, and precision medicine to improve outcome for PCRC.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"174"},"PeriodicalIF":1.5000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent advances in pediatric colorectal cancer: a systematic review.\",\"authors\":\"Navdeep Dhoat, Shilpa Sharma\",\"doi\":\"10.1007/s00383-025-06076-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To study the recent advances in Pediatric colorectal cancer (PCRC), including molecular profiling, clinical and genetic characteristics, screening guidelines, and treatment strategies.</p><p><strong>Method: </strong>A PubMed search was done on 25 March 2025, by using search words Pediatric colorectal cancer with a filter of last year, yielding 414 articles. On screening for relevant articles focusing on molecular profiles or screening guidelines in pediatric cases, 10 articles were selected, describing 38 tumors in 36 pediatric patients.</p><p><strong>Results: </strong>Clinical features of PCRC included unexplained abdominal pain, abdominal distension, vomiting, hematochezia, intestinal obstruction, and intestinal intussusception. Salient molecular profiling included distinct genomic landscapes in pediatric/ young adult CRC compared to adult CRC, and differences in WNT and PI3K-AKT pathways. PCRC had a significantly higher frequency of RNF43 mutations versus APC mutations in adults, suggesting age-related differences in WNT pathway activation. PCRC showed a peculiar profile with CDK6 amplification and enrichment of lysine degradation pathway. Few PCRC cases showed mismatch repair (MMR) deficiency, suggesting second-hit somatic alterations. The recent advances highlight in identifying hereditary cancer susceptibility syndromes and utility of indocyanine green fluorescence-guided surgery.</p><p><strong>Conclusion: </strong>Distinct molecular signatures in PCRC underscore the need for age-specific treatment strategies, multidisciplinary care, and precision medicine to improve outcome for PCRC.</p>\",\"PeriodicalId\":19832,\"journal\":{\"name\":\"Pediatric Surgery International\",\"volume\":\"41 1\",\"pages\":\"174\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Surgery International\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00383-025-06076-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Surgery International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00383-025-06076-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Recent advances in pediatric colorectal cancer: a systematic review.
Purpose: To study the recent advances in Pediatric colorectal cancer (PCRC), including molecular profiling, clinical and genetic characteristics, screening guidelines, and treatment strategies.
Method: A PubMed search was done on 25 March 2025, by using search words Pediatric colorectal cancer with a filter of last year, yielding 414 articles. On screening for relevant articles focusing on molecular profiles or screening guidelines in pediatric cases, 10 articles were selected, describing 38 tumors in 36 pediatric patients.
Results: Clinical features of PCRC included unexplained abdominal pain, abdominal distension, vomiting, hematochezia, intestinal obstruction, and intestinal intussusception. Salient molecular profiling included distinct genomic landscapes in pediatric/ young adult CRC compared to adult CRC, and differences in WNT and PI3K-AKT pathways. PCRC had a significantly higher frequency of RNF43 mutations versus APC mutations in adults, suggesting age-related differences in WNT pathway activation. PCRC showed a peculiar profile with CDK6 amplification and enrichment of lysine degradation pathway. Few PCRC cases showed mismatch repair (MMR) deficiency, suggesting second-hit somatic alterations. The recent advances highlight in identifying hereditary cancer susceptibility syndromes and utility of indocyanine green fluorescence-guided surgery.
Conclusion: Distinct molecular signatures in PCRC underscore the need for age-specific treatment strategies, multidisciplinary care, and precision medicine to improve outcome for PCRC.
期刊介绍：
Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children.
The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include:
-Review articles-
Original articles-
Technical innovations-
Letters to the editor
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