{"title":"利用二氧化碳作为可持续碳源的自养细菌生产聚羟基烷酸酯。","authors":"Ganesan Sathiyanarayanan, Sandra Esteves","doi":"10.3389/fbioe.2025.1545438","DOIUrl":null,"url":null,"abstract":"<p><p>The persistence of fossil fuel-based plastics poses significant environmental challenges, prompting increased research into biodegradable polyhydroxyalkanoate (PHA) polymers derived from cost-effective and sustainable resources. Different microorganisms can produce PHA amongst carbon dioxide (CO<sub>2</sub>)-assimilating autotrophic organisms, particularly noteworthy in carbon capture and utilization (CCU). Autotrophic bacteria have evolved to utilize either light (photoautotrophy) or inorganic chemicals (chemolithoautotrophy) to capture CO<sub>2</sub>, which powers their primary and secondary metabolic activities. This review explores the diversity of PHA-producing autotrophs, the metabolic pathways implicated in autotrophic PHA accumulation, and recent progress in photoautotrophs and chemolithoautotrophs regarding PHA synthesis using CO<sub>2</sub>. Additionally, microbial electrosynthesis for converting CO<sub>2</sub> to PHA is also discussed. Genetic engineering strategies are also emphasized for the autotrophic synthesis of PHA. This review also addresses the challenges and prospects for sustainable PHA production using CO<sub>2</sub>.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1545438"},"PeriodicalIF":4.8000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174442/pdf/","citationCount":"0","resultStr":"{\"title\":\"Autotrophic bacterial production of polyhydroxyalkanoates using carbon dioxide as a sustainable carbon source.\",\"authors\":\"Ganesan Sathiyanarayanan, Sandra Esteves\",\"doi\":\"10.3389/fbioe.2025.1545438\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The persistence of fossil fuel-based plastics poses significant environmental challenges, prompting increased research into biodegradable polyhydroxyalkanoate (PHA) polymers derived from cost-effective and sustainable resources. Different microorganisms can produce PHA amongst carbon dioxide (CO<sub>2</sub>)-assimilating autotrophic organisms, particularly noteworthy in carbon capture and utilization (CCU). Autotrophic bacteria have evolved to utilize either light (photoautotrophy) or inorganic chemicals (chemolithoautotrophy) to capture CO<sub>2</sub>, which powers their primary and secondary metabolic activities. This review explores the diversity of PHA-producing autotrophs, the metabolic pathways implicated in autotrophic PHA accumulation, and recent progress in photoautotrophs and chemolithoautotrophs regarding PHA synthesis using CO<sub>2</sub>. Additionally, microbial electrosynthesis for converting CO<sub>2</sub> to PHA is also discussed. Genetic engineering strategies are also emphasized for the autotrophic synthesis of PHA. This review also addresses the challenges and prospects for sustainable PHA production using CO<sub>2</sub>.</p>\",\"PeriodicalId\":12444,\"journal\":{\"name\":\"Frontiers in Bioengineering and Biotechnology\",\"volume\":\"13 \",\"pages\":\"1545438\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-06-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174442/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Bioengineering and Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3389/fbioe.2025.1545438\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1545438","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Autotrophic bacterial production of polyhydroxyalkanoates using carbon dioxide as a sustainable carbon source.
The persistence of fossil fuel-based plastics poses significant environmental challenges, prompting increased research into biodegradable polyhydroxyalkanoate (PHA) polymers derived from cost-effective and sustainable resources. Different microorganisms can produce PHA amongst carbon dioxide (CO2)-assimilating autotrophic organisms, particularly noteworthy in carbon capture and utilization (CCU). Autotrophic bacteria have evolved to utilize either light (photoautotrophy) or inorganic chemicals (chemolithoautotrophy) to capture CO2, which powers their primary and secondary metabolic activities. This review explores the diversity of PHA-producing autotrophs, the metabolic pathways implicated in autotrophic PHA accumulation, and recent progress in photoautotrophs and chemolithoautotrophs regarding PHA synthesis using CO2. Additionally, microbial electrosynthesis for converting CO2 to PHA is also discussed. Genetic engineering strategies are also emphasized for the autotrophic synthesis of PHA. This review also addresses the challenges and prospects for sustainable PHA production using CO2.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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