薯蓣内生镰刀菌L46新α-吡啶酮的分离纯化

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-06-18 DOI:10.1002/cbdv.202500223

Ruo-Dan Tian, Ying-Fei Zhao, Fei-Fan Wang, Song-Jie Zhan, Chun-Nan Wen, Miao Liu, Bing-Ji Ma

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引用次数: 0

摘要

从薯蓣叶片内生真菌镰刀菌（Fusarium sp. L46）中分离到2个新的α-吡啶酮衍生物Fusarilactones D和E(1和2)，以及4个已知化合物phomapyrone C(3)、fusarester C(4)、neovasifuranone B(5)和neovasifuranone A(6)。它们的结构是通过1D和2D核磁共振光谱，hresms和旋光度测量来确定的。测定化合物3 ~ 5对胰脂肪酶的抑制活性。

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New α-Pyrones From Endophytic Fusarium Sp. L46 Isolated From Dioscorea opposita.

Fusarilactones D and E (1 and 2), two new α-pyrone derivatives, and four known compounds, namely, phomapyrone C (3), fusarester C (4), neovasifuranone B (5), and neovasifuranone A (6), were isolated from Fusarium sp. L46, an endophytic fungus isolated from Dioscorea opposita leaves. Their structures were determined using 1D and 2D NMR spectra, HRESIMS, and optical rotation measurements. Compounds 3-5 were assessed for their inhibitory activity on pancreatic lipase.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.