艾司西酞普兰联合喹硫平致抑郁症患者3度房室传导阻滞1例。

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.62347/JAKR2090
Chen-Jie Ge, Li-Lei Lei, Shi-Liang Wang, Xu-Qiang Hu
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引用次数: 0

摘要

与使用艾司西酞普兰和喹硫平相关的三度房室传导阻滞(AVB)是罕见的,报道的病例有限。我们提出一个病例药物引起的第三度AVB在一个老年患者接受治疗抑郁症。一名70岁有抑郁症史的妇女最初用米纳西普兰和阿普唑仑治疗,但由于治疗效果不足而改变了治疗方案。在开始使用艾司西酞普兰和喹硫平两周后,她出现了三度AVB。心电图显示窦性心律伴完全房室传导阻滞,房室交界性逸出节律,QT间期延长,心率45bpm。实施紧急起搏器植入。该病例强调了艾司西酞普兰和喹硫平可能诱发严重的心传导异常,特别是在老年患者中。在处方这些药物时,定期心电图监测是必要的,以尽量减少恶性心律失常的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Third-degree atrioventricular block induced by escitalopram and quetiapine in a patient with depression: a case report.

Third-degree atrioventricular block (AVB) associated with the use of escitalopram and quetiapine is rare, with limited cases reported. We present a case of drug-induced third-degree AVB in an elderly patient undergoing treatment for depression. A 70-year-old woman with a history of depression was initially treated with milnacipran and alprazolam, but the regimen was altered due to insufficient therapeutic response. Two weeks after initiating escitalopram and quetiapine, she developed third-degree AVB. Electrocardiogram (ECG) revealed sinus rhythm with complete AV block, atrioventricular junctional escape rhythm, QT interval prolongation, and a heart rate of 45 bpm. Emergency pacemaker implantation was performed. This case highlights the potential for escitalopram and quetiapine to induce serious cardiac conduction abnormalities, particularly in elderly patients. Regular ECG monitoring is essential when prescribing these agents to minimize the risk of malignant arrhythmia.

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American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
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