Guangxi Chen, Min Zhang, Jing Zhou, Tao Wang, Mei Zhu, Zhiqiang Liu
{"title":"多导睡眠图对阻塞性睡眠呼吸暂停低通气综合征合并高血压及继发性动脉粥样硬化的诊断价值。","authors":"Guangxi Chen, Min Zhang, Jing Zhou, Tao Wang, Mei Zhu, Zhiqiang Liu","doi":"10.62347/CYRN3387","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the utility of polysomnography (PSG) in diagnosing obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with hypertension who develop secondary atherosclerosis, and to identify effective indicators for predicting arterial sclerosis.</p><p><strong>Methods: </strong>140 OSAHS patients with hypertension diagnosed in Jiujiang NO. 1 People's Hospital from January 2021 to December 2023 were enrolled in this retrospective study and divided into two groups based on the presence of arteriosclerosis: the control group (without arteriosclerosis) and the research group (with arteriosclerosis). Univariate analysis, Pearson correlation analysis, and multivariate logistic regression analysis were used to identify independent factors affecting arteriosclerosis. The diagnostic performance of these factors were evaluated using a receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Compared with the control group, the research group showed significantly higher levels of fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein (LDL), apnea-hypopnea index (AHI), systolic blood pressure (SBP), and intima-media thickness (IMT), and a significantly lower level of minSpO<sub>2</sub> (<i>P</i><0.05). In patients with OSAHS and hypertension, FBG, TG, LDL, AHI, SBP, and IMT were positively correlated with secondary atherosclerotic diseases (r=0.273, 0.249, 0.190, 0.294, 0.198, 0.506, all <i>P</i><0.05), while minSpO<sub>2</sub> was negatively correlated with secondary atherosclerotic diseases (r=-0.199, <i>P</i><0.05). FBG, TG, LDL, AHI, minSpO<sub>2</sub>, SBP, and IMT were identified as independent risk factors for the development of atherosclerosis in patients with OSAHS and hypertension (<i>P</i><0.05), with the area under the receiver operator characteristic curves of 0.668, 0.647, 0.636, 0.690, 0.636, 0.608, 0.805, and 0.922 for single and combined tests, respectively (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The AHI and minSpO<sub>2</sub> from PSG can predict arteriosclerosis. Combining them with FBG, TG, LDL, SBP, and IMT improves the accuracy of risk assessment.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3928-3938"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170409/pdf/","citationCount":"0","resultStr":"{\"title\":\"The diagnostic value of polysomnography in obstructive sleep apnea-hypopnea syndrome patients with hypertension and secondary atherosclerosis.\",\"authors\":\"Guangxi Chen, Min Zhang, Jing Zhou, Tao Wang, Mei Zhu, Zhiqiang Liu\",\"doi\":\"10.62347/CYRN3387\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the utility of polysomnography (PSG) in diagnosing obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with hypertension who develop secondary atherosclerosis, and to identify effective indicators for predicting arterial sclerosis.</p><p><strong>Methods: </strong>140 OSAHS patients with hypertension diagnosed in Jiujiang NO. 1 People's Hospital from January 2021 to December 2023 were enrolled in this retrospective study and divided into two groups based on the presence of arteriosclerosis: the control group (without arteriosclerosis) and the research group (with arteriosclerosis). Univariate analysis, Pearson correlation analysis, and multivariate logistic regression analysis were used to identify independent factors affecting arteriosclerosis. The diagnostic performance of these factors were evaluated using a receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Compared with the control group, the research group showed significantly higher levels of fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein (LDL), apnea-hypopnea index (AHI), systolic blood pressure (SBP), and intima-media thickness (IMT), and a significantly lower level of minSpO<sub>2</sub> (<i>P</i><0.05). In patients with OSAHS and hypertension, FBG, TG, LDL, AHI, SBP, and IMT were positively correlated with secondary atherosclerotic diseases (r=0.273, 0.249, 0.190, 0.294, 0.198, 0.506, all <i>P</i><0.05), while minSpO<sub>2</sub> was negatively correlated with secondary atherosclerotic diseases (r=-0.199, <i>P</i><0.05). FBG, TG, LDL, AHI, minSpO<sub>2</sub>, SBP, and IMT were identified as independent risk factors for the development of atherosclerosis in patients with OSAHS and hypertension (<i>P</i><0.05), with the area under the receiver operator characteristic curves of 0.668, 0.647, 0.636, 0.690, 0.636, 0.608, 0.805, and 0.922 for single and combined tests, respectively (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The AHI and minSpO<sub>2</sub> from PSG can predict arteriosclerosis. Combining them with FBG, TG, LDL, SBP, and IMT improves the accuracy of risk assessment.</p>\",\"PeriodicalId\":7731,\"journal\":{\"name\":\"American journal of translational research\",\"volume\":\"17 5\",\"pages\":\"3928-3938\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170409/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of translational research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.62347/CYRN3387\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/CYRN3387","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
The diagnostic value of polysomnography in obstructive sleep apnea-hypopnea syndrome patients with hypertension and secondary atherosclerosis.
Objective: To investigate the utility of polysomnography (PSG) in diagnosing obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with hypertension who develop secondary atherosclerosis, and to identify effective indicators for predicting arterial sclerosis.
Methods: 140 OSAHS patients with hypertension diagnosed in Jiujiang NO. 1 People's Hospital from January 2021 to December 2023 were enrolled in this retrospective study and divided into two groups based on the presence of arteriosclerosis: the control group (without arteriosclerosis) and the research group (with arteriosclerosis). Univariate analysis, Pearson correlation analysis, and multivariate logistic regression analysis were used to identify independent factors affecting arteriosclerosis. The diagnostic performance of these factors were evaluated using a receiver operating characteristic (ROC) curve analysis.
Results: Compared with the control group, the research group showed significantly higher levels of fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein (LDL), apnea-hypopnea index (AHI), systolic blood pressure (SBP), and intima-media thickness (IMT), and a significantly lower level of minSpO2 (P<0.05). In patients with OSAHS and hypertension, FBG, TG, LDL, AHI, SBP, and IMT were positively correlated with secondary atherosclerotic diseases (r=0.273, 0.249, 0.190, 0.294, 0.198, 0.506, all P<0.05), while minSpO2 was negatively correlated with secondary atherosclerotic diseases (r=-0.199, P<0.05). FBG, TG, LDL, AHI, minSpO2, SBP, and IMT were identified as independent risk factors for the development of atherosclerosis in patients with OSAHS and hypertension (P<0.05), with the area under the receiver operator characteristic curves of 0.668, 0.647, 0.636, 0.690, 0.636, 0.608, 0.805, and 0.922 for single and combined tests, respectively (P<0.05).
Conclusion: The AHI and minSpO2 from PSG can predict arteriosclerosis. Combining them with FBG, TG, LDL, SBP, and IMT improves the accuracy of risk assessment.
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