子宫腔操作史对供体精子体外受精胚胎移植临床和新生儿结局的影响。

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.62347/SVQB2127
Qin-Zi Mo, Ying Huang, Rong Li, Qian Huang
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引用次数: 0

摘要

目的:探讨子宫腔手术对首次体外受精-供精胚胎移植(IVF-ET with DS)患者临床及新生儿结局的影响。方法:本回顾性队列研究纳入599例首次IVF-ET合并DS的不孕症患者。将患者分为两组:有子宫腔手术史组(n=457)和无子宫腔手术史组(n=142)。前者进一步细分为刮宫术(n=67)、宫腔镜(n=292)和复杂子宫手术(n=98)。主要结局包括临床妊娠结局(着床率、临床妊娠率、流产率、活产率)和新生儿结局(胎龄、出生体重和身长、胎龄小(SGA)、胎龄大(LGA)、早产发生率)。结果:非手术组、刮宫组、复合手术组临床妊娠结局差异无统计学意义(P < 0.05)。宫腔镜组流产率明显低于对照组,而着床率、临床妊娠率、活产率均高于对照组(P < 0.05)。多因素分析证实,宫腔镜病史与妊娠结局改善和流产率降低独立相关,特别是在两个年龄组(< 35岁和≥35岁)中。各组新生儿结局无显著差异(P < 0.05)。结论:宫腔镜病史与首次IVF-ET合并DS患者的着床率、临床妊娠率、活产率和较低的流产率相关,且不影响新生儿结局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of uterine cavity manipulation history on clinical and neonatal outcomes for in vitro fertilization-embryo transfers with donor sperm.

Objective: To evaluate the effect of prior uterine cavity procedures on clinical and neonatal outcomes in patients undergoing first-time in vitro fertilization-embryo transfer with donor sperm (IVF-ET with DS).

Methods: This retrospective cohort study included 599 infertility patients receiving their first IVF-ET with DS. Patients were categorized into two groups: those with a history of uterine cavity operation group (n=457) and the group with no history (n=142). The former was further subdivided into curettage (n=67), hysteroscopy (n=292), and complex uterine operations (n=98). Primary outcomes included clinical pregnancy outcomes (implantation rate, clinical pregnancy rate, miscarriage rate, and live birth rate) and neonatal outcomes (gestational age, birth weight and length, incidence of being small for gestational age [SGA], large for gestational age [LGA], and preterm birth).

Results: No significant differences were found in clinical pregnancy outcomes between the non-operative, curettage, and complex operation groups (all P > 0.05). However, the hysteroscopy group showed significantly lower miscarriage rates and higher implantation, clinical pregnancy, and live birth rates (all P < 0.05). Multivariate analysis confirmed that hysteroscopy history was independently associated with improved pregnancy outcomes and reduced miscarriage rates, particularly in both age groups (< 35 and ≥ 35 years). No significant differences in neonatal outcomes were observed across all groups (all P > 0.05).

Conclusion: A history of hysteroscopy is associated with improved implantation, clinical pregnancy, and live birth rates, and a lower miscarriage rate in patients undergoing first IVF-ET with DS, without affecting neonatal outcomes.

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American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
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