肛瘘的代谢途径:为创新治疗铺平道路。

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.62347/UWZM3553
Minjie Wang, Yibin Pan, Xi Zhang, Chen Pan, Yongqing Cao
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引用次数: 0

摘要

背景:肛瘘,特别是隐腺形式肛瘘,是一种常见但具有挑战性的疾病,通常导致愈合不良和复发性感染。研究与肛瘘相关的代谢变化可能为其潜在机制提供有价值的见解,并有助于开发更有效的治疗方法。方法:本研究对不同类型肛瘘患者和健康对照者的血清样本进行综合分析。进行代谢组学分析以确定组间代谢途径的差异。结果:分析显示肛瘘患者的代谢发生了显著变化,尤其是脂肪酸代谢、鞘脂代谢和氨基酸代谢。值得注意的是,代谢物如肾上腺酸、LysoPC (22:5n6)和PC(18:0/22:4)与肛瘘的进展显著相关。这些代谢物可以作为疾病的生物标志物,在区分急性和慢性阶段方面具有特别的相关性。结论:该研究为肛瘘的代谢基础提供了新的见解,确定了可能在其进展中起关键作用的特定代谢途径和代谢物。这些发现可能有助于开发更有效的靶向治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic pathways in anal fistula: paving the way for innovative treatments.

Background: Anal fistula, particularly in its cryptoglandular form, is a common yet challenging condition to treat, often resulting in poor healing and recurrent infections. Investigating the metabolic changes associated with anal fistula may offer valuable insights into its underlying mechanisms and assist in the development of more effective treatments.

Methods: This study conducted a comprehensive analysis of serum samples from patients with various types of anal fistula and healthy controls. Metabolomic profiling was performed to identify differences in metabolic pathways between the groups.

Results: The analysis revealed significant metabolic alterations in patients with anal fistula, particularly in fatty acid metabolism, sphingolipid metabolism, and amino acid metabolism. Notably, metabolites such as adrenic acid, LysoPC (22:5n6), and PC (18:0/22:4) were significantly associated with the progression of anal fistula. These metabolites could serve as biomarkers for the condition, with particular relevance in differentiating between acute and chronic stages.

Conclusion: The study provides new insight into the metabolic basis of anal fistula, identifying specific metabolic pathways and metabolites that may play crucial roles in its progression. These findings may contribute to the development of targeted therapies for more effective treatment.

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来源期刊
American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
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