体育活动与常见妇科疾病的因果关系:一项双样本孟德尔随机化研究。

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.62347/PGYY9493
Mengyu Fu, Xiaoyue Zhu, Jie Chen, Jiewen Guan, Hongmei Ding, Qinqin Gao, Songbing Qin
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引用次数: 0

摘要

目的:虽然体育活动(PA)模式在流行病学上与妇科疾病有关,但建立因果关系仍不确定。这项孟德尔随机化(MR)研究评估了前列腺癌表型与妇科疾病之间的因果关系。方法:利用欧洲血统女性全基因组关联研究(GWAS)数据,分析8种妇科疾病和4种PA仪器。主要的反方差加权(IVW)估计通过敏感性分析(MR-Egger,加权中位数,MR-PRESSO)补充,以解决多效性和异质性。结果:我们的MR显示了亚型特异性的影响:快乐散步[OR = 0.63, 95% CI: 0.41-0.96],剧烈运动[OR = 0.34, 95% CI: 0.16-0.74]和其他运动[OR = 0.70, 95% CI: 0.49-0.99]降低了ER+乳腺癌(BC)的风险,而休闲屏幕时间增加了风险(OR = 1.08, 95% CI: 1.004-1.163)。只有其他运动可以预防ER- BC (OR = 0.60, 95% CI: 0.38-0.96)。运动频率与子宫内膜癌(EC)呈负相关(步行:OR = 0.20;剧烈运动:OR = 0.06;其他运动:OR = 0.41)和子宫内膜异位症(剧烈运动:OR = 0.17;其他运动:OR = 0.26),但与久坐行为呈正相关(EC: OR = 1.36)。卵巢囊肿(OCS)风险随着步行(OR = 0.34)和其他运动(OR = 0.28)而降低,但随着屏幕时间的增加而增加(OR = 1.23)。相反,步行与多囊卵巢综合征(PCOS)呈强正相关(OR = 31.48),剧烈运动与PCOS呈负相关(OR = 0.004)。宫颈癌(CC)、卵巢癌(OC)或子宫肌瘤(UF)之间没有因果关系。结论:这是第一个磁共振证据,证明了PA对妇科疾病的不同因果影响,特别强调了运动方式对ER+ BC、EC和ES的特异性保护。多囊卵巢综合征的矛盾关系需要进行机制调查。研究结果强调前列腺癌是一种可改变的预防因素,并提倡针对女性健康的亚型量身定制的运动指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Causal relationship between physical activity and common gynecologic conditions: a two-sample Mendelian randomization study.

Objective: While physical activity (PA) patterns are epidemiologically linked to gynecologic pathologies, establishing causality remains uncertain. This Mendelian randomization (MR) study evaluated causal relationships between PA phenotypes and gynecologic disorders.

Methods: Using European-ancestry female genome-wide association study (GWAS) data, we analyzed eight gynecologic disorders and four PA instruments. Primary inverse-variance weighted (IVW) estimates were supplemented by sensitivity analyses (MR-Egger, weighted median, MR-PRESSO) to address pleiotropy and heterogeneity.

Results: Our MR revealed subtype-specific effects: walking for pleasure [OR = 0.63, 95% CI: 0.41-0.96], strenuous sports [OR = 0.34, 95% CI: 0.16-0.74], and other exercises [OR = 0.70, 95% CI: 0.49-0.99]) reduced ER+ breast cancer (BC) risk, while leisure screen time increased risk (OR = 1.08, 95% CI: 1.004-1.163). Only other exercises protected against ER- BC (OR = 0.60, 95% CI: 0.38-0.96). Exercise frequency inversely correlated with endometrial cancer (EC) (walking: OR = 0.20; strenuous sports: OR = 0.06; other exercises: OR = 0.41) and endometriosis (ES) (strenuous sports: OR = 0.17; other exercises: OR = 0.26), but was positively associated with sedentary behavior (EC: OR = 1.36). Ovarian cyst (OCS) risk decreased with walking (OR = 0.34) and other exercises (OR = 0.28), yet increased with screen time (OR = 1.23). Paradoxically, walking showed strong positive (OR = 31.48) and strenuous exercise inverse (OR = 0.004) associations with polycystic ovary syndrome (PCOS). No causal links emerged for cervical cancer (CC), ovarian cancer (OC), or uterine fibroids (UF).

Conclusion: This first MR evidence demonstrates PA's differential causal effects on gynecologic disorders, particularly highlighting exercise modality-specific protection against ER+ BC, EC, and ES. Paradoxical PCOS associations warrant mechanistic investigation. Findings underscore PA as a modifiable preventive factor and advocate for subtype-tailored exercise guidelines in women's health.

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American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
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